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Dosages Induction Meds Flashcards

1
Q

What is the dose for Thiopental?
How much is in the brain 30 minutes post-administration? Why?

A
  • 4mg/kg IV
  • 10% in the braine after admin. Rapid redistribution to skeletal muscles occurs.
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2
Q

What is the IV methohexital dose?
What if it needs to be given rectally?

A
  • 1.5 mg/kg IV
  • 20 - 30 mg/kg PR
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3
Q

For Propofol, what are the doses for:
1. Induction
2. Maintenance
3. Conscious sedation

A
  1. Induction = 1.5 - 2.5 mg/kg IV
  2. Maintenance = 100 - 300 μg/kg/min
  3. Conscious sedation = 25 - 100 μg/kg/min
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4
Q

For Propofol, what are the doses for:
1. Induction
2. Maintenance
3. Conscious sedation

A
  1. Induction = 1.5 - 2.5 mg/kg IV
  2. Maintenance = 100 - 300 μg/kg/min
  3. Conscious sedation = 25 - 100 μg/kg/min
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5
Q

What is the induction dose of propofol in adults? Children?

A
  • Adults: 1.5-2.5 mg/kg IV
  • Pediatrics: higher doses due to larger central volume and clearance rate.
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6
Q

What is the conscious sedation dose of propofol?

A
  • 25 - 100 μg/kg/min
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7
Q

What is the sub-hypnotic dosing for propofol?

A
  • 10 - 15 mg IV, followed by 10 mcg/kg/min
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8
Q

What is the anti-pruritic dosing of propofol?

A
  • 10 mg IV
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9
Q

What is the anti-convulsant dosing of propofol?

A

1mg/kg IV

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10
Q

What is the induction dose for etomidate?

A
  • 0.3 mg/kg IV
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11
Q

What can be administered with etomidate to prevent involuntary myoclonic movements?

A

Fentanyl 1-2 μg/kg IV

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12
Q

What is the induction dose of ketamine IV?
What if it is given IM?

A
  • 0.5 - 1.5 mg/kg IV
  • 4 - 8 mg/kg IM
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13
Q

What is the maintenance dosing of ketamine?

A
  • 0.2 - 0.5 mg/kg IV
  • 4 - 8 mg/kg IM
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14
Q

What is the subanesthetic/analgesic dose of ketamine?

A
  • 0.2 - 0.5 mg/kg IV
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15
Q

What is the post-operative sedation and analgesia dosing for ketamine in pediatric cardiac surgery cases?

A

1-2 mg/kg/hour

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16
Q

What is the neuraxial epidural analgesia dosing of ketamine?
What about intrathecal route?

A
  • 30mg epidural
  • 5 - 50 mg via intrathecal/spinal/subarachnoid
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17
Q

What drug and dosing should be used to treat excessive salivary secretions from ketamine administration?

A

Glycopyrrolate: 0.2mg

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18
Q

At what dosing will the ICP increasing effects of ketamine plateau?

A
  • 2mg/kg IV
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19
Q

What is the dosage of morphine?
When does it peak?
How long does it last?

A
  • 1 - 10 mg IV
  • Peak: 15 - 30 minutes
  • Duration: 4-5 hours
20
Q

What is the primary indication for meperidine?
What dose is used?

A
  • Post-operative shivering
  • 12.5mg IV
21
Q

What is the analgesia dosage of fentanyl?
Induction dose?

A
  • Analgesia: 1 - 2 μg/kg IV
  • Induction: 1.5 - 3 μg/kg IV
22
Q

What is the intrathecal dosage of fentanyl?

23
Q

What is the adult oral dose of fentanyl?
Pediatric?

A
  • Adult: 5 - 20 mcg/kg
  • Peds: 15 - 20 mcg/kg
24
Q

What is the transdermal dose of fentanyl?

A
  • 75 - 100 μg (18 hours steady delivery)
25
What is the analgesia dose of sufentanil?
- Analgesia: 0.1 - 0.4 μg/kg IV
26
What is the induction dose of sufentanil?
18.9 mcg/kg IV
27
What is the alfentanil induction dose? What about laryngoscopy dose? What about maintenance?
- Induction: 150 - 300 μg/kg IV - Laryngoscopy: 15 - 30 μg/kg IV - Maintenance: 25 - 150 μg/kg/hr IV with inhaled anesthetics
28
What is the induction dose of remifentanil?
- 1 μg/kg IV over 1 min
29
What is the maintenance dosing of remifentanil?
- 0.005 - 2 μg/kg/min IV
30
How potent is hydromorphone? What dose should be given? What benefits does hydromorphone have over morphine?
- 5x more potent than morphine - 0.5mg IV → 1-4 mg total - **No histamine release & no active metabolites.**
31
What is the dose of codeine for cough suppression? Analgesia?
- Cough: 15mg - Analgesia: 60mg (= about 5mg morphine)
32
What is the sufentanil intraop dose? What is the infusion dose?
intraop: 0.3 - 1μg/kg IV infusion: 0.5 - 1μg/kg/hr IV
33
What is the chronic pain dose of Pentazocine? What dose and route would be equivalent to morphine 10mg?
- 10 - 30mg IV or 50 mg PO - 20-30mg IM = 10mg morphine
34
What is the naloxone IV push dose? Continuous infusion?
- 1-4 mcg/kg IV - 5 mcg/kg/hr IV infusion
35
What dose of naloxone is use for shock?
- > 1mg/kg IV
36
How does nalmefene's potency compare to naloxone? What is it's dose and max?
- equipotent to naloxone - 15 - 25 mcg IV q2-5min (max of 1 mcg/kg)
37
What is the dosage for Celebrex?
200 to 400 mg PO QD
38
What is the duration & dose of Ondansetron? (pediatric?)
Duration/plasma half life: 4 hours Dose: Adults: 4 - 8 mg IV Dose: Pediatrics: 0.1 mg/kg IV
39
What is the dose for Dexamethasone (Decadron)? What is the MOA of Dexamethasone (Decadron)?
4 - 8 mg IV MOA: Anti-inflammatory; inhibition of phospholipase and cytokines and stabilization of cellular membrane.
40
According to the TXWES medication guide, what are the doses for Acetaminophen (Ofirmev), Ketorlac (Toradol), & Ibuprofen (Caldor).
Slide 62
41
What is the IV bolus and infusion dose of lidocaine? When should the infusion be terminated?
- 1 to 2 mg/kg IV bolus over 2-4 min. - 1 to 2 mg/kg/hr infusion - Terminated within 12-72 hours.
42
What is the PO dose of preemptive Gabapentin? When should we give it? What is it's MOA?
300-1200mg PO 1-2 hrs prior to OR GABA analogue
43
For Ofirmev, what is the Dose, Peak effect time (PO/IV), and duration?
44
For Ketorolac, what is the: - MOA - Peak - Dosing
MOA: Inhibits PG synthesis by inhibiting COX 1 and COX 2 Peak: 45 to 60 minutes IV Dose: 15 to 30mg q6h (1/2 dose in elderly) Max Dose: 60-120mg QD
45
What is Mg⁺⁺ dosing for the following two situations? Preop: Intraop:
- Preop: 50 mg/kg IV - Intraop: 8 mg/kg/hr IV
46
Ibuprofen: - MOA - Dose - Peak - Excretion - Contraindications
- COX 1 & 2 Inhibition = ↓ PG synthesis - 200 - 800 mg q6h (max:3200mg QD) - 1-2 hours - Urine & Bile -C/I: Nephropathy, CABG, bleeding disorders, wound healing
47
Using multimodal anesthesia, what 2 meds might we give in preop to better control pain later?
Acetaminophen 1000 mg PO, Gabapentin 300 mg PO

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