Dr In Training

Question 1

MHC

Answer 1

Allow leukocytes and cels to communicate

Question 2

Mhc1

Answer 2

On all nucleated cells, antigen presenting cells, platelets, never RBC

Willl present self or antigen

HLA-A, B, C

Presents antigen synthesized endogenously

One long chain a1,a2,a3
One short b1

Peptide bingeing groove between a1,q2

Question 3

MHCII

Answer 3

On antigen presenting cell

Loci is HLA-DP, all have two letters

Bind CD4

Present non endogenous

2 equal chain, a1, a2, b1, b2

Question 4

Loaded after invariant chain is acidified in endosomes

Answer 4

Class II

MHC I loaded through RER

Question 5

APC

Answer 5

TH1, TH2, TH17, Treg

Question 6

What activates TH1

Answer 6

IFN-y, IL12

Question 7

What does TH1 make

Answer 7

IFN-y

Question 8

What does TH1 activate

Answer 8

Macrophages, cytotoxic T cells

Question 9

Problem with TH1

Answer 9

Increased susceptibility to microbacterial diseases

Question 10

What activate TH2

Answer 10

IL2, IL4

Question 11

Where are TH2

Answer 11

Mucosa gut and nasal passages

Question 12

What TH2 secrete

Answer 12

IL4, 5, 6, 10, 13

Question 13

What TH2 activate

Answer 13

Eosinophils and promote IgE for nasty worms

Question 14

What makes TH17

Answer 14

TGFB, IL6,

Question 15

What TH17 make

Answer 15

IL17, 21, 22

Question 16

Job TH17

Answer 16

Recruit neutrophils for fungal and bacterial cells

Question 17

Treg

Answer 17

Keep other cells from getting ahead

Question 18

What induce Treg

Answer 18

TGFB, IL12

Question 19

What T reg make

Answer 19

TGFB, IL10, IL35

Question 20

IL4 IL10 from TH2

Answer 20

Inhibit TH1

Question 21

IFNy from TH1

Answer 21

Inhibit TH1 and TH17

Question 22

IL6 from TH2

Answer 22

Inhibits T reg

Question 23

T cell precursor

Answer 23

In bone marrow

Question 24

Where T cell go to mature

Answer 24

Thymus

Question 25

In thymic cortex

Answer 25

Positive selection -assures T cell can bind MHC and if better with class I or 2 Class I CD8 MHC2 CD4

Question 26

One differentiated

Answer 26

Moves to medulla for negative selection

Question 27

Negative selection

Answer 27

Strong bind self antigen-apoptosis, AIRE allows tissue restricted self antigens to be expressed (with out Polyendocrine immune syndrome1)

Question 28

CD8

Answer 28

Cytotoxic kill virus infected, neoplastic, and donor graft cells

Question 29

CD4

Answer 29

Helper and differentiate into subsets

Question 30

IL1

Answer 30

Fever and acute inflammation hen come in contact with pathogen-generalized inflammation Chemokine secretion to get more wbc

Question 31

IL6

Answer 31

Fever Stimulates acute phase protein(increase CRP)

Question 32

Il8

Answer 32

Main chemotactic factor for neutrophils | -clean up isle 8

Question 33

Interleukin 12

Answer 33

Induces differentiation Activates NK cells

Question 34

TNFa

Answer 34

Activates endothelium and vascular leak (can lead to hypotension and shock)

Question 35

Those were macrophages

Answer 35

Ok

Question 36

T cell

Answer 36

IL2 IL3

Question 37

IL2

Answer 37

Stimulates growth of helper T cells and cytotoxic T cells

Question 38

IL3

Answer 38

Supports growth and differentiation of bone marrow in stem cells

Question 39

TH1

Answer 39

IFNy

Question 40

IFNY

Answer 40

Stimulates macrophages, inhibits TH2 cells, activating NK (antiviral)

Question 41

TH2

Answer 41

IL4, 5, 13

Question 42

IL4,

Answer 42

Induces T cells->TH3 Promotes growth of B cells Promotes class switching of IgE->IgG Ain’t too proud 2 BEG 4 work

Question 43

IL5

Answer 43

Promotes growth and differentiation of B cells Enhances switching to IgA Stimulates growth and differentiation of eosinophils

Question 44

IL10

Answer 44

Modulates inflammatory response Decrease MHCII and TH1 cytokines Inhibits macrophages and dendritic cells Secreted by Treg and TH2

Question 45

HOT T Bone steak

Answer 45

Il1 hot Il2 stilate T cell IL3 stimulate bone marrow for more leukocytes IL4 IgE production Il5 IgA production IL6 stimulate aKute phase protein production

Question 46

Leukocyte extravasation

Answer 46

Getting wbc out of bloodstream and into tissues 4 steps

Question 47

1

Answer 47

Neutrophil sticky ROLLING on vascular endothelium, bounding , rolling and endothelium can select by selectin

Question 48

E selectin

Answer 48

Endothelial cells

Question 49

P selectin

Answer 49

Platelets

Question 50

L selectin

Answer 50

Leukocytes

Question 51

Are selectin always expressed

Answer 51

No acute phase cytokine il1, 6, TNFa make endothelial cells stickier a

Question 52

Step 2

Answer 52

Tight binding ICAM-1 on endothelial cells LFA1 on leukocytes (integrin)

Question 53

Step 3

Answer 53

Diapedesis

Question 54

Leukocyte go in between PECAM1 in intracellular junctions go through

Answer 54

Ok

Question 55

Step 4

Answer 55

Migration | Through interstitial to place need to go based on chemotactic signals

Question 56

Neutrophil chemotactic factos

Answer 56

C5a IL8, LTB4, kallirein

Question 57

Ataxia-telangiectasia

Answer 57

Defective DNA repair Ataxic gait facial telangiectasis Poor smooth pursuit with the eyes Elevated AFP

Question 58

Bruton agammaglobuliminemia

Answer 58

X linked tyrosine kinase defiency Low levels of all IgG isotopes

Question 59

Digeorge disease

Answer 59

2q11 deletion Defective development of 3rd and 4th branchial pouches Hypocalcemia Thymic aplasia

Question 60

SCID

Answer 60

Defective DNA repairadenosine deaminase defiency Infections, diarrhea, failure to thrive Thymic aplasia (absent thymic shadow on new born )