DR. Tucket's video presentation 1a

Question 1

Supersensitivity

Answer 1

Pertains to an antagonist

Question 2

Down Regulation

Answer 2

Pertains to an agonist

Question 3

Plasma and Tissue Concentration

Question 4

CYP450 Enzymes (Plasma Concentration)

Answer 4

example: CYP2D6

. root= CYP
. family = 2
. subfamily = D
. gene = 6

Question 5

TMAX
CMAX
CMIN
AUC

Question 6

Noncompetitive Antagonism (rare)

Question 7

Additivity, Synergism,

Question 8

Mechanisms involved in solute transport across biological membranes

Answer 8

. passive diffusion
. facilitated diffusion
. active transport
. primary active transport
. secondary active transport

Question 9

Passive Diffusion

Answer 9

. occurs down an electrochemical potential gradient
. three processes: partition from the aqueous to the lipid phase, diffusion across the lipid bilayer, and repartition into the aqueous phase on the opposite side.

Question 10

Facilitated Diffusion

Answer 10

. across the plasma membrane and facilitated by a membrane transporter.
. form of transporter-mediated membrane that does not require energy input.
. steady state achieved when the electrochemical potentials of a compound on both sides of the membrane are equal.

Question 11

Active Transport

Answer 11

. requires the input of energy.
. transport of solutes against their electrochemical gradients
. leads to the concentration of solutes on one side of the membrane and the creation of potential energy in the formed electrochemical gradient.