Goodman & Gillman Chapter 2

Question 1

Passive Diffusion

Answer 1

. In passive transport the drug molecule penetrates by diffusion along a concentration gradient in the lipid bilayer.
. steady state concentrations
. dependent on the electrochemical gradient for the ion and on pH differences across the membrane.
. weak acids and bases

Question 2

Facilitated Diffusion

Answer 2

. carrier mediated transport process

Question 3

Active Transport

Answer 3

. the direct requirement for energy, capacity to move solute against an electrochemical graduent, saturability, selectivity, and competitive inhibition by cotransported compounds
. Na+ and K+-ATPase are important example of active transport mechanism

Question 4

Paracellular Transport

Answer 4

. p. 15- In the vascular compartment, paracellular passage of solutes and fluid through intercellular gaps is sufficiently large that passive transfer across the endothelium of capillaries and postcapillary vnules is generally limted by blood flow.

Question 5

Albumin