DR.AlmasLec#4

Question 1

Innate immunity is present even before exposure to antigen.

Answer 1

True

Question 2

Defensins are toxic to human cells.

Answer 2

False

Question 3

Toll-like receptors are expressed by T cells.

Answer 3

False

Question 4

PRRs recognize PAMPs and DAMPs.

Answer 4

True

Question 5

B-1 cells mostly produce IgA antibodies

Answer 5

False

Question 6

Scavenger receptors can recognize lipoteichoic acid.

Answer 6

True

Question 7

Inflammasomes activate IL-10 production.

Answer 7

False

Question 8

Mannose receptors promote phagocytosis.

Answer 8

True

Question 9

FMLP receptors are mainly expressed by phagocytes.

Answer 9

True

Question 10

RIG-I detects viral RNA with a 5’ cap structure.

Answer 10

False

Question 11

Which molecule helps TLR4 recognize LPS?

Answer 11

MD2

Question 12

Which type of immunity is stimulated by innate immunity?

Answer 12

Adaptive immunity

Question 13

Which Toll-like receptor recognizes bacterial flagellin?

Answer 13

TLR5

Question 14

What are the main cytokines elevated during an acute phase response?

Answer 14

IL-6 and IL-1

Question 15

The presence of uric acid crystals can trigger which inflammasome?

Answer 15

NLRP3

Question 16

Dectin-1 specifically binds to which fungal component?

Answer 16

β-glucans

Question 17

Which plasma protein binds phosphorylcholine on bacterial membranes?

Answer 17

CRP

Question 18

Collectins like SP-A are found mainly in which organ?”

Answer 18

Lungs

Question 19

Which receptor family is involved in cytoplasmic detection of viral RNA?

Answer 19

RIG-like receptors (RLRs)

Question 20

The main scavenger receptor that acts with TLR2/6 is:

Answer 20

CD36

Question 21

(“NOD-like receptors are located in which part of the cell?”

Answer 21

Cytoplasm

Question 22

What characterizes the receptors of innate immunity?

Answer 22

Encoded in germline with limited diversity

Question 23

Which component activates caspase-1 in inflammasome formation?

Answer 23

ASC adaptor protein

Question 24

Plasma levels of CRP increase by how much during infection?

Answer 24

1000-fold

Question 25

Ficolins primarily recognize which bacterial component?

Answer 25

N-acetylglucosamine

Question 26

Which cytokine suppresses the function of macrophages?

Answer 26

IL-10

Question 27

Which of the following is a soluble opsonin produced in response to infection?

Answer 27

Mannose-binding lectin (MBL)

Question 28

Activation of TLRs leads to activation of which transcription factor?

Answer 28

NF-κB

Question 29

Which innate receptor recognizes bacterial peptides with formylmethionine?

Answer 29

FMLP receptor

Question 30

RIG-I and MDA5 lead to the production of

Answer 30

Type I interferons