Drug Absorption Demo Flashcards
(3 cards)
1
Q
Phenobarbital
A
used to Tx seizuressedative, anesthesia induction, anxiolyticShort acting, but longer to anesthesia, longer livedsubstitution @ C5 to S –> less lipid soluble, more polarlikely to develop tolerancesevere toxicities (coma, resp dep, death)contraindicated in pregnancyinduces P450 & its own metabolism
2
Q
Thiopental
A
similar to Pentobarbitolsedativesubstitution @ C2 carbonyl, more hydrophobic/lipophilic/lipid solubleeven faster acting, but also shorter durationanesthesia inductionLethal OD
3
Q
Pentobarbital
A
sedative, anesthesia induction1st drug usedlipophilicvery short actingLethal OD
