Drug action Flashcards
1
Q
what are nitrogen mustards?
A
-derived from sulphur mustards -Predominant crosslink is between the N7 of guanine on two strands - an interstrand crosslink -Stops enzymes such as DNA polymerase being able to separate the strands and thus stops replication.
2
Q
what is the mechanism for alkylation?
A
3
Q
what is the michael addition mechainsm with cycsteine and glutathione?
A
