Drug-target interactions Flashcards
1
Q
what is the physiological pH?
A
7.4
2
Q
what can you find out from the physiological pH?
A
Need to know which functional groups are charged at this pH
– Typesofbindinginteractions
– Solubility(uptakeanddistribution)
– Potential salt forms (for formulation)
3
Q
Acids react with water formula?
A
HA+H2O⇌H3O+ +A−
4
Q
Bases react with water formula?
A
B+H2O⇌BH+ +OH−
5
Q
rules to work out if it is NOT an aliphatic amine:
A
- Is there a nitrogen-containing/amine functional group?
- Does it have a single bond attached?
- Is that single bond attached to a double bond?
6
Q
what does pKa measure?
A
measure of dissociation
-Roughly the pH at which a functional group is 50% charged
