Drug Chemistry Flashcards

(49 cards)

1
Q

What act was passed in 1956?

A

Narcotic Drug Control Act

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2
Q

What was the Narcotic Drug Control Act (1956)

A
  • Increased penalties for illicit use of drugs
  • Stiff jail sentences imposed
  • Possible death penalty for selling drugs to a minor
  • FDA could recommend control of new “dangerous drugs”
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3
Q

What was the Bureau of Narcotics renamed to?

A

Bureau of Narcotics and Dangerous Drugs

-To enforce new laws

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4
Q

When was the Comprehensive Controlled Substances Act. And what was it.

A
  • 1970
  • All drug laws either repealed or updated to make all controlled substances federally regulated
  • Federal jurisdiction supersedes state laws
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5
Q

The Bureau of Narcotics and Dangerous Drugs moved to what department and was renamed what?

A
  • Department of Justice

- Drug Enforcement Administration

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6
Q

Who determined which substances were controlled through the FDA?

A

Secretary of Health and Human Services

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7
Q

What were the criteria for determining which substances were controlled?

A
  • Pharmacological effects
  • Ability to induce psychological dependence or physical addiction
  • Legitimate medical use
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8
Q

What drugs are schedule 1?

A

Heroin
LSD
Marijuana
Methaqualone

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9
Q

What are schedule 1 drugs? (Abuse/Dependence/Medical)

A

-The drug has a high potential for abuse.
-The drug causes physical addiction or psychological dependence.
-The drug has no accepted medical use
There is a lack of accepted safety for use of the drug under medical supervision.

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10
Q

What drugs are schedule 2?

A

Morphine
PCP
Cocaine
Methadone

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11
Q

What is schedule 2?

A
  • The drug has a high potential for abuse
  • Has an accepted medical use
  • Abuse may lead to severe psychological or physical dependence
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12
Q

What drugs are schedule 3?

A
  • Anabolic steroids
  • Less than or equal to 90 mg codeine with aspirin or acetaminophen AKA Tylenol
  • Ketamine
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13
Q

What is schedule 3?

A
  • Some potential for abuse, less than 1/2
  • Has medical use
  • Abuse may lead to moderate or low dependence
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14
Q

What drugs are schedule 4?

A
  • Propoxyphene
  • Pentazocine
  • Benzodiazepines
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15
Q

What is schedule 4?

A
  • Low potential for abuse
  • Has medical use
  • Limited dependence
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16
Q

What drugs are schedule 5?

A

OTC cough medicines with codeine

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17
Q

What is schedule 5?

A

Low potential for abuse
Has medical use
Limited dependence

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18
Q

How are carisoprodol and meprobamate related?

A

Meprobamate is a metabolite of carisoprodol

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19
Q

Which schedules carry high penalties for possession, manufacturing and sale of the drugs?

A

Schedules 1 and 2

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20
Q

Who can be charged if a drug user dies from an overdose of certain drugs?

21
Q

Which act is still the law governing law enforcement activity today?

A

Comprehensive Controlled Substances act

22
Q

What can also be listed as controlled substances?

A

Precursors or chemicals used to manufacture drugs

-The precursors may not have a pharmacological activity of effect as the resulting drug

23
Q

The DEA developed a model state law entitled what?

A

Uniform Controlled Substances Act

24
Q

What does Pharmacophore mean?

A

The portion of a chemical structure that confers the activity of the substance.

25
What are naturally occurring substances?
Drugs found in plants or animals
26
Name some naturally occurring drugs and how they are taken. (Hallucinogens)
-Marijuanna leaves are dried and smoked -Psilocybin mushrooms are ingested -Peyote cactus buttons are ingested Bufo alvarius toad secretes a psychoactive drug
27
What is the main psychoactive drug in marijuana leaves?
∆9-Tetrahydrocannabinol
28
What are also naturally occuring substances which are extracted prior to ingestion?
Plant extracts
29
List some naturally occurring substances which are extracted from plants prior to ingestion.
- Cocaine which is extracted from the coca plant - Morphine and Codeine which is extracted from opium poppy - Epredrine which is extracted from the ephedra sinicacoca plant - Kava kava which is extracted from kava root
30
What can the levels of morphine in poppy seeds range between?
4 to 200 mg/kg
31
Is it possible to test positive for a urine opiate immunoassay screen after consuming poppy seed paste?
Yes
32
What are semi synthetic substances?
Naturally occuring substances but are chemically altered
33
List some semi synthetic drugs and what they come from.
- Heroin is produced by the diacytylation of morphine - LSD is manufactured from lysergic acid - Oxycodone is synthesized from thebaine
34
The presence of what has been used as a biomarker to determine if morphine came from poppy seeds or from heroin.
Thebaine
35
What are synthetic drugs?
Completely manmade
36
List some synthetic drugs (4).
Amphetamines Barbiturates PCP Fentanyl
37
What are the drug classifications by chemical stucture?
- Sympathomimetic amines (SMAs)/ Amphetamines - Barbiturates - Benzodiazepines - Fentanyls - Opiates - Tricyclic Antidepressants (TCAs)
38
What are the drug classifications by pharmacology?
Stimulant Depressant Narcotic Hallucinogen
39
What is the most popular way to classify drugs by?
Pharmacology
40
How are drugs classified by pharmacology?
By psychoactive effects
41
What do stimulants do?
- Elevate mood - Stimulate CNS - More energy - Greater alertness - Increased strength - Heighten senses - Better sexual experiences - Possibly increased intelligence
42
Amphetamines were developed as a substitute for the weaker stimulant ____.
Ephedrine
43
What are some uses/treatments of amphetamines?
- Treatment of narcolepsy - Appetite suppressant - ADHD
44
Which drug is widely abused by college students?
Amphetamines
45
What were the original "designer drugs" and were referred to as love drugs in the 1960s?
Methamphetamine MDMA MDA
46
What is the smokable form of meth?
Ice
47
What did early synthesis of Meth from pseudoephedrine include?
lithium (batteries) and ammonia (farm fertilizer)
48
Two ways of synthesizing meth?
Sudafed (one pot method; shake and bake) | Leuckart reaction
49
Synthesis via sudafed has a reduction of what group?
Hydroxyl