Drug delivery Flashcards
(11 cards)
What is included in the anterior segment of the eye
cornea
pupil
lens
cillary body
What is included in the posterior segment of the eye
conjunctiva
sclera
choroid
retina
optic nerve
What are the 3 barriers to ocular delivery
Blood ocular
corneal
pre-corneal
What are the 2 blood ocular barriers
Blood aqueous barrier
Blood retinal barrier
What are the 2 pre-corneal barriers
Capacity of the cul-de-sac
Loss of lacrimal fluid
What happens to do cul-de-sac capacity as a barrier
the space becomes reduced
Less fluid can get into the eye
Lower therapeutic effect
What is the purpose of the lacrimal fluid
Drainage of eye fluid
What contributes to decreased drug absorption in the pre-corneal barriers
Tear formation
Non-formation absorption
What is the rate limiting step in ocular delivery
Trans-corneal permeation
What are the 3 layers of the corneal barrier
Epithelium
Stroma
Endothelium
What are the 3 cells involved in the BBB structure
Pericytes
Astrocytes
Endothelium
