Drug Design And Discovery

Question 1

Define drug.

Answer 1

A chemical substance used to prevent or cure disease.

Question 2

What is the drug discovery pipeline?

Answer 2

1) Pool of potential drug molecules
2) hit compounds
3) lead compound
4) clinical candidate
5) preclinical development
6) manufacturing
7) clinical trials
8) marketing, use, monitoring

Question 3

Define Pharmokinetics

Answer 3

How the drug is process and transported by the body over time.

Question 4

Define Pharmodynamics

Answer 4

Effects of the drug on the body overtime.

Question 5

What is the theraputic window?

Answer 5

The concentration of the drug where it is effective but not toxic.

Question 6

what is Phase 1 of clinical trials?

Answer 6

Trials of small numbers of volunteers, testing ofr safety of the drug.

Question 7

What is phase 2 of clinical trials?

Answer 7

• can be blind or double blind trials.
• tested on patient with the condition the drug was made for.
• larger number of partidipants
• safety os still monitored.

Question 8

what are the properties of drugs that result in rapid excretion in the urine? why?

Answer 8

high polarity of hydrophilicity
kidney filtration - filtrated waster-soluable molecules from the blood into the urine.
reduced reabsorption - Hydrophilic drugs are unlikely to be reabsorbed into the bloodstream in the renal tubules, as they cannot easily cross lipid membranes.
direct elimination - Water-soluble drugs stay in aqueous environment of plasma and urine, promoting faster renal clearance.