Drug Discovery

Question 1

ADME

Answer 1

Absorption, distribution, metabolism, and excretion, also known as “ADME,” are the internal processes that describe how a drug moves throughout and is processed by the body. ADME is assessed through the collection of data in clinical pharmacology studies and helps explain the PK processes at play for any given drug.

Question 2

A systemic toxin

Answer 2

is one that affects the entire body or many organs rather than a specific site. For example, potassium cyanide is a systemic toxicant in that it affects virtually every cell and organ in the body by interfering with the cell’s ability to utilize oxygen.

Question 3

IND applications

Answer 3

Investigator-Initiated Investigational New Drug (IND) Applications.

Question 4

NDA

Answer 4

New drug application