drug drug interactions

Question 1

what is a pharmaceutical drug interaction

Answer 1

physical changes to the drug

Question 2

what two drugs can you not mix in the syringe

Answer 2

aminoglycosides and beta lactams

Question 3

what drugs should you be careful with flavorings

Answer 3

fluoroquinolones

Question 4

what drugs will precipitate in calcium containing fluids

Answer 4

tetracyclines

Question 5

and drug that has HCl should not be given with what

Answer 5

alkaline fluids

Question 6

what is a pharmacokinetic interaction

Answer 6

absorption, distribution, metabolism and elimination changes

Question 7

what drugs have a decreased absorption in acidic (low pH)

Answer 7

penicillin, erythromycin, omeprazole

Question 8

what drugs have decreased absorption in basic (higher pH)

Answer 8

azole antifungals

Question 9

what drugs will chelate in Al or Mg (sucralfate)

Answer 9

FQs and tetras

Question 10

microsomal induction

Answer 10

eats up drugs faster, decreased efficacy

Question 11

what are our microsomal inducers

Answer 11

rifampin, phenobarbital, griseofulvin, phenytoin

Question 12

microsomal inhibition

Answer 12

decreases first pass metabolism, drug accumulates = higher concentrations

Question 13

microsomal inhibiting drugs

Answer 13

azole fungals, chloramphenicol, erythromycin, glucocorticoids (Dex), quinidine

Question 14

what is the only protein binding interaction we care about

Answer 14

phenylbutazone and warfarin

Question 15

what is a pharmacodynamic interaction

Answer 15

giving two drugs to cause the same effect. agonist/antagonists- reversals of a drug.