MDR1 and friends Flashcards
(16 cards)
what is the MDR1 mutation
mutation in the ABCB1 gene that encodes the p-glycoprotein efflux pumps
what are p-glycoprotein pumps and why do we care
in the CNS and protected sites to pump drugs out. no pump= increased toxicity risk
what breeds do we think of for MDR1
collies, aussies, whippets, mixed breeds
major drugs to think about for MDR1 dogs
MLs, emetics, appetite stimulants, butorphanol, acepromazine, chemo, cyclosporine, grapiprant
what do the clinical signs of overdose look like for MDR1
myelosupression, GI signs, CNS depression, tremors, prolonged sedation
general dose recommendations for MDR1 dogs
decrease dose 25% for heterozygotes, 50% for homozygotes
can an animal acquire MDR1 like signs
yes
what drugs are p-glycoprotein pump inhibitors
ketoconazole, cyclosporine, spinosads
what drugs upregulate p glycoprotein pumps causing decreased CNS signs
rifampin, glucocorticoids, phenobarbital
what mutation do dobermans and rotties have
CYB5R3
who can we not give sulfas to
dobermans and rotties
what does the CyB5R3 gene do
responsible for the clearance of sulfas
what should we remember about greyhounds/sight hounds
they can have mutations that cause prolonged clearance of sedation and anesthetic drugs
what should we consider in sight hounds when sedating them
lowering the dose
what else should we remember about dolicephalic breeds and genetics
they can have delayed bleeding. like 24-48hr delays.
what mutation causes delayed bleeding in doliocephalic breeds
SERPINF2. regulates fibrinolysis
