Drug Evaluations and Pharmacogenetics Flashcards Preview

Pharmacology > Drug Evaluations and Pharmacogenetics > Flashcards

Flashcards in Drug Evaluations and Pharmacogenetics Deck (18):
1

Preclinical Safety Testing

on animals
in vitro
not completely reliable data when transferred to human use

2

Phase 1

20-50
tested on healthy people
to see if the drug is safe

3

Phase 2

100-200
tested on sick people
to see if the drug is effective

4

Phase 3

1000-6000
Safety and efficacy
double blind

5

A new drug must file a ______ to begin human trials

Investigational New Drug Application

6

After passing human trials, drugs file a ______ to hit open market

New Drug Application

7

Phase 4

Marketing

8

Orphan Drugs

for diseases affecting less than 200,000
often will not get enough funding/ profit because of so few affected

9

Missense SNP

change in structure or function of protein

10

Nonsense SNP

stop codon

11

Synonymous/ Silent SNP

does not affect structure or function of protein

12

CYP2C9

metabolizes drugs with small TI- warfarin
if has this allele warfarin will not metabolize and will increase risk of bleeding

13

CYP2C19

metabolizes proton pump inhibitors

14

CYP2D6 and Codeine

ultra rapid metabolizer
increased opioid medicated affects if have 2 alleles

15

CYP2D6 Poor Metabolizer

little or no function

16

CYP2D6 Ultra Rapid Metabolizer

greater than normal function

17

CYP2C19 Poor Metabolizer

increased efficacy of proton pump inhibitors
removes Helicobacter pylori faster

18

CYP3A4

metabolizes most drugs