drug excretion Flashcards by Charlotte Watkins | Brainscape

Flashcards in drug excretion Deck (11)

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1

where in the body is the drug prepared for elimination?

liver

2

what are examples of phase 1 reactions?

oxidation, reduction, hydrolysis

3

what are examples of phase 2 reactions?

conjugation
-glucuronidation, sulphation, methylation, acetylation

4

where does the most extensive excretion occur?

renal excretion of water soluble metabolites-urine
liver metabolism and excretion-bile
lungs-inhales gases and volatile fractions of other drugs

5

where are small portions of drugs excreted?

sweat
saliva
tears

6

what diseases interfere with normal function of main excretory organs?

renal disease
-chronic renal failure
-drug doses must be reduced
liver disease
-liver failure
-drug doses must be reduced

7

what is plasma half life?

time taken to eliminate half a drug

8

what is first order kinetic?

drug metabolism increases as drug concentration increases
excretion by passive diffusion only

9

what is zero order kinetics?

drug metabolism is at a fixed rate-active process
irrespective of drug concentration
can lead to the drug accumulation if saturation exceeded

10

what will too frequent dosing lead to?

plasma levels that may be toxic
-depends on the drug's therapeutic index

11

what will too infrequent dosing lead to ?

sub-therapeutic plasma levels and no clinical effect