DRUG INTERACTION PART 1

Question 1

The drug whose activity is affected in the interaction.

Answer 1

Object Drug

Question 2

The entity that triggers an interaction.

Answer 2

Precipitant

Question 3

warfarin and aspirin

Answer 3

drug-drug interaction

Question 4

ace inhibitor and k+ sparring

Answer 4

drug-drug interaction

Question 5

Anti-biotic and oral contraception

Answer 5

drug-drug interaction

Question 6

Digoxin and diuretics

Answer 6

drug-drug interaction

Question 7

grapefruit and statins

Answer 7

drug food interaction

Question 8

Spinach and warfarin

Answer 8

drug food interaction

Question 9

dairy product and anti biotic

Answer 9

drug food interaction

Question 10

alcohol and pain killers

Answer 10

drug-food interaction

Question 11

st. john wort and antidepressant

Answer 11

drug-herb interaction

Question 12

gingko biloba and blood thinners

Answer 12

drug-herb interaction

Question 13

ginseng and blood pressure medication

Answer 13

drug-herb interaction

Question 14

garlic and blood thinners

Answer 14

drug-herb interaction

Question 15

biotin and troponin level test

Answer 15

drug-laboratory test interaction

Question 16

Aspirin and liver fxn test

Answer 16

drug-laboratory test interaction

Question 17

Diuretics and electrolytes

Answer 17

drug-laboratory test interaction

Question 18

what is the bacteria present in yakult?

Answer 18

probiotic : Lactobacillus casei Shirota

Question 19

Beta blocker and asthma

Answer 19

drug -dse interaction

Question 20

Nsaids and peptic ulcer dse

Answer 20

drug -dse interaction

Question 21

anti cholinergic and glaucoma

Answer 21

drug -dse interaction

Question 22

Antacid and tetracycline

Answer 22

drug -chemical interaction

Question 23

chlorine and nitrate meds

Answer 23

drug -chemical interaction

Question 24

alcohol and disulfiram

Answer 24

drug -chemical interaction

Question 25

antibiotic and water pollution

Answer 25

drug - environment interaction

Question 26

cold weather and beta blockers

Answer 26

drug - environment interaction

Question 27

sunlight and tetracycline

Answer 27

drug - environment interaction

Question 28

effects of DI: -increased or decreased effect. -Enzyme inhibition or induction

Answer 28

Generally quantitative-

Question 29

Seldom qualitative

Answer 29

-Rapid or slower effect. -Synergism or antagonism

Question 30

precipitation

Answer 30

-New or increased adverse effects. -harmful

Question 31

desirable or undesirable: Alaxan® is made up of paracetamol and ibuprofen.

Answer 31

beneficial; This would be beneficial in the management of pain and prevent inflammation, respectively by its components of paracetamol and ibuprofen.

Question 32

CONTRIBUTING FACTORS: 2 or more drugs that are being taken by a patient.

Answer 32

Polypharmacy

Question 33

CONTRIBUTING FACTORS: there is now a cumulation of drugs from the first and second physician.

Answer 33

Multiple Physicians

Question 34

CONTRIBUTING FACTORS: Aspirin has several pharmacological effects such as anti-inflammatory, antithrombotic, analgesic, anticancer

Answer 34

Multiple Pharmacologic Effects

Question 35

CONTRIBUTING FACTORS: illness of the patient becomes more

Answer 35

Multiple Disease/Predisposing Illness

Question 36

CONTRIBUTING FACTORS: Patient doubles the amount of drug that would be taken with the notion that higher doses would give better effects.

Answer 36

Poor Patient Compliance

Question 37

CONTRIBUTING FACTORS: As patients age, they might become forgetful.

Answer 37

Advancing Age of Patient

Question 38

CONTRIBUTING FACTORS: drug has low therapeutic index

Answer 38

Drug Related Factor

Question 39

in vitro; occurs BEFORE drugs are administered

Answer 39

pharmaceutical interaction

Question 40

pharmaceutical interaction

Answer 40

o Physical incompatibilities o Chemical incompatibilities

Question 41

In vivo; occurs AFTER drugs are administered

Answer 41

pharmacological interaction

Question 42

pharmacological interaction

Answer 42

-PHARMACOKINETICS -PHARMACODYNAMICS

Question 43

ADME

Answer 43

PHARMACOKIETICS

Question 44

SYNERGISM, POTENTIATION, ADDITION AND ANTAGONISM

Answer 44

PHARMACODYNAMIC

Question 45

Complexation and adsorption

Answer 45

ABSORPTION INTERACTION

Question 46

Altered in Gastrointestinal (GI) pH

Answer 46

ABSORPTION INTERACTION

Question 47

Alteration in GUT motility

Answer 47

ABSORPTION INTERACTION

Question 48

Inhibition of GI enzymes

Answer 48

ABSORPTION INTERACTION

Question 49

Alteration in GI flora

Answer 49

ABSORPTION INTERACTION

Question 50

Malabsorption Syndrome

Answer 50

ABSORPTION INTERACTION

Question 51

ASA (aspirin) + Warfarin=Bleeding/hemorrhage due to displacement of warfarin since it is less protein bound

Answer 51

Distribution interactions

Question 52

more enzymes are produced. Faster metabolism- Decrease in the pharmacological effect of the object drug

Answer 52

Enzyme induction; madaling ma excreet

Question 53

Slower metabolism; Greater concentration of the drug in the blood. Resulting to more

Answer 53

Enzyme inhibition; madaling maabsorb

Question 54

Alteration in renal blood flow

Answer 54

Excretion interactions

Question 55

Alteration urine pH

Answer 55

Excretion interactions

Question 56

Competition for active secretions

Answer 56

Excretion interactions

Question 57

Forced diuresis

Answer 57

Excretion interactions

Question 58

taking one stimulant or CNS stimulant with another stimulant would result to an increase stimulant action resulting form the sum of its individual drug

Answer 58

Addition or summation

Question 59

1+1=0

Answer 59

antagonism

Question 60

Remdesivir (antiviral agent) is taken with clarithromycin (microlide antibiotic)

Answer 60

synergism

Question 61

aspirin and warfarin resulting to bleeding/hemorrhage

Answer 61

potentiation