Midterms

Question 1

Anong concept: Acid + acid = absorb

Answer 1

Changes in Gastric pH

Question 2

Anong concept: Chelation and Complexation

Answer 2

Complexation

Question 3

Anong concept:
↑ GER= ↑ GI motility=↓absorption=↓GET

Answer 3

Changes in GI motility

Question 4

Anong concept:
Rifamycin’s + OCP’s

Answer 4

Alteration of GI flora

Question 5

Anong concept:
Aluminum based drug + TDDS

Answer 5

ALTERATION OF TRANSDERMAL DRUG ABSORPTION

Question 6

Anong concept:
ALBUMIN AND ALPHA 1-GLYCOPROTIEN IN DRUG DISTRIBUTION

Answer 6

PROTEIN BINDING

Question 7

SICKFACES.COMGQR (INHIBITOR)
SCRAPGPT (INDUCER)

Answer 7

ENZYME INHIBITION AND INDUCTION

Question 8

COMPETETIVE TO RENAL TUBULAR TRANSPORTERS

Answer 8

ALTERED EXCRETION

Question 9

Absorb or excrete:
Lipophilic

Answer 9

absorb

Question 10

Absorb or excrete:
Ionized

Answer 10

excrete

Question 11

Acidic or basic:
Intestine

Answer 11

Basic

Question 12

Acidic or basic:
stomach

Answer 12

Acidic

Question 13

Acidic or basic:
Aspirin

Answer 13

acidic

Question 14

Acidic or basic:
dipyridamole

Answer 14

acidic

Question 15

Acidic or basic:
Diazepam

Answer 15

acidic

Question 16

Acidic or basic:
furosemide

Answer 16

Acidic

Question 17

Acidic or basic:
Diclofenac

Answer 17

Acidic

Question 18

Acidic or basic:
OH- Containing drugs

Answer 18

basic

Question 19

Acidic or basic:
Bicarbonates

Answer 19

basic

Question 20

Acidic or basic:
proton pump inhibitors (prazoles)

Answer 20

basic

Question 21

enteric or not:
Bonamine (antiemetic)

Answer 21

not

Question 22

enteric or not: Aspirin
(nsaid)

Answer 22

enteric/ acidic
A Dic O sa aFam, tig Bente

Question 23

enteric or not: Diclofenac
(nsaid)

Answer 23

enteric/ acidic
A Dic O sa aFam, tig Bente

Question 24

enteric or not: Omeprazole
(PPI)

Answer 24

enteric/Basic drug
A Dic O sa aFam, tig Bente

Question 25

enteric or not: Famotidine (GERD)

Answer 25

enteric A Dic O sa aFam, tig Bente

Question 26

enteric or not: Bentyl (antispasmodic)

Answer 26

enteric A Dic O sa aFam, tig Bente

Question 27

case: Kapag nagtake ng diazepam at aspirin together. what happens

Answer 27

Aspirin will be metabolized in the stomach. increase risk of PUD.

Question 28

Weak acid+ weak base

Answer 28

Ionized so excreted. Almost all drug are weak acid and weak base. if pinagsama ang acid + base= formation of salt also.

Question 29

(+) charged + (-) charged

Answer 29

ionization

Question 30

It is a type of complexation where metal is used.

Answer 30

Chelation - charged metal

Question 31

binding of ion Charged particles bind

Answer 31

complexation

Question 32

Identify if chelation or complexation: Cholestyramine + digoxin/ warfarin

Answer 32

complexation

Question 33

Identify if chelation or complexation: Metamucil + digoxin/ warfarin and salicylates

Answer 33

complexation

Question 34

Identify if chelation or complexation: Na polystyrene sulfate + Antacid

Answer 34

complexation??

Question 35

Identify if chelation or complexation: Sevelamer + ciprofloxacin/ Levothyroxine

Answer 35

complexation

Question 36

Identify if chelation or complexation: Activated charcoal + iron sulfate

Answer 36

chelation

Question 37

Identify if chelation or complexation: Vitamins + tetracycline

Answer 37

chelation

Question 38

Identify if chelation or complexation: vitamins + fluoroquinolones

Answer 38

chelation

Question 39

increase or decrease GI motility: Bisacodyl, cascara, senna

Answer 39

↑ GI motility

Question 40

increase or decrease GI motility: Sorbitol

Answer 40

↑ GI motility

Question 41

increase or decrease GI motility: Psyllium

Answer 41

↑ GI motility

Question 42

increase or decrease GI motility: tegaserod

Answer 42

↑ GI motility

Question 43

increase or decrease GI motility: Asapride

Answer 43

↑ GI motility

Question 44

increase or decrease GI motility: Methylnaltrexone

Answer 44

↑ GI motility

Question 45

increase or decrease GI motility: Metoclopramide

Answer 45

↑ GI motility

Question 46

increase or decrease GI motility: Erythromycin

Answer 46

↑ GI motility

Question 47

increase or decrease GI motility: Hyosyamine (IBS), Anticholinergic

Answer 47

↓ GI motility

Question 48

increase or decrease GI motility: propantheline (antimuscarinic)

Answer 48

↓ GI motility

Question 49

increase or decrease GI motility: TCA's (tricyclic antidepressants)

Answer 49

↓ GI motility - anti cholinergic side effect

Question 50

increase or decrease GI motility: Opioids

Answer 50

↓ GI motility - agonist of mu-opioid receptor

Question 51

increase or decrease GI motility: Diphenhydramine (antihistamine)

Answer 51

↓ GI motility - anti cholinergic effect

Question 52

Prokinetic drug

Answer 52

Asapride

Question 53

selective agonist of serotonin in GI

Answer 53

Asapride

Question 54

selective antagonist of the mu-opioid receptor

Answer 54

Methylnaltrexone - treat opioid-induced constipation

Question 55

Blocks GI dopamine receptor 1,2,3 in the GUT

Answer 55

Metoclopramide -prokinetic and anti-emetic

Question 56

Anti-biotics/Colonic cleansing + vit K

Answer 56

no synthesis of vit K - vit K defficiency

Question 57

rifamycin + OCP

Answer 57

sub therapeutic effect of OCP

Question 58

Anti-biotic/colonic cleansing + Digoxin

Answer 58

increased digoxin digoxin is metabolized in GUT bacteria called EGGERHELLA

Question 59

Epinephrine + Lidocaine TDDS

Answer 59

prolong anesthetic effect of lidocaine

Question 60

Aluminum based drug + TDDS

Answer 60

drugs in TDDS will not be absorbed

Question 61

Menthol + TDDs

Answer 61

chang in skin pH will cause irritation= inflammation (skin will buldge)= pores constrict = TDDs drugs won't pass through

Question 62

when drugs stay in the blood stream what is affected in ADME?

Answer 62

Distribution

Question 63

will a drug ellicit effect when it is binded to a protein?

Answer 63

no

Question 64

protein binding can prolong duration of action

Answer 64

yes

Question 65

bound drugs acts as a reservoir

Answer 65

yes

Question 66

protein binding protects drug from metabolism and excretion

Answer 66

yes

Question 67

which protein does it bind to: WARFARIN (ACIDIC DRUG)

Answer 67

ALBUMIN

Question 68

which protein does it bind to: SALICYLATES

Answer 68

ALBUMIN

Question 69

which protein does it bind to: DIGOXIN

Answer 69

ALBUMIN

Question 70

which protein does it bind to: IBUPROFEN

Answer 70

ALBUMIN

Question 71

Which protein does it bind to: FLUOXETINE ANTI-DEPRESSANTS

Answer 71

ALBUMIN

Question 72

which protein does it bind to: CITALOPRAM ANTI -DEPRESSANT

Answer 72

ALBUMIN

Question 73

which protein does it bind to: KETOCONAZOLE ANTI FUNGAL

Answer 73

ALBUMIN

Question 74

which protein does it bind to: PHENYTOIN ANTI EPILEPTIC

Answer 74

ALBUMIN

Question 75

which protein does it bind to: PREDNISOLONE CORTICOSTEROID

Answer 75

ALBUMIN

Question 76

which protein does it bind to: NAFCILLIN BETA LACTAM ANTIBIOTIC

Answer 76

ALBUMIN

Question 77

Which protein does it bind to: CARBAMAZEPINE ANTI CONVULSANT

Answer 77

ALPHA 1 ACID GLYCOPROTEIN

Question 78

which protein does it bind to: LIDOCAINE ARRHYTHMIA/ ANESTHESIA

Answer 78

ALPHA 1 ACID GLYCOPROTEIN

Question 79

Which protein does it bind to: LOPINAVIR ANTI- RETROVIRAL PROTEASE INHIBITOR

Answer 79

ALPHA 1 ACID GLYCOPROTEIN

Question 80

which protein does it bind to: METHADONE ANALGESIC (SYNTHETIC OPIOID AGONIST)

Answer 80

ALPHA 1 ACID GLYCOPROTEIN

Question 81

which protein does it bind to: PRAZOSIN (HIGH BLOOD ; ANTI ADRENERGIC AGENT )

Answer 81

ALPHA 1 ACID GLYCOPROTEIN

Question 82

which protein does it bind to: QUININE (MALARIA AND BABESIOSIS)

Answer 82

ALPHA 1 ACID GLYCOPROTEIN

Question 83

which protein does it bind to: COCAINE

Answer 83

ALPHA 1 ACID GLYCOPROTEIN

Question 84

ERYTHROMYCIN

Answer 84

ALPHA 1 ACID GLYCOPROTEIN

Question 85

Identify if the concept is for normal drug or for pro drug: Enzyme inhibition: increased effect

Answer 85

normal drug

Question 86

Identify if the concept is for normal drug or for pro drug: enzyme induction: increased effect

Answer 86

pro drug - the enzyme in charged for activating the drug is induced

Question 87

Identify if the concept is for normal drug or for pro drug: enzyme inhibition: decreased effect

Answer 87

prodrug - the enzyme in charge of activating a drug is inhibited

Question 88

Identify if the concept is for normal drug or for pro drug: enzyme inducer: decrease effect

Answer 88

normal drug

Question 89

fluconazole + warfarin

Answer 89

inhibitor Fluconazole inhibits the enzyme responsible in metabolizing warfarin = bleeding

Question 90

grapefruit juice + drug

Answer 90

inhibitor grapefruit is an inhibitor

Question 91

ssri's +mao's

Answer 91

inhibitor - LEADS TO SEOTONIN SYNDROME SSRI- INHIBITS SEROTONIN RE UPTAKE MAO- PREVENTS METABOLISM OF SEROTONINSEROTONIN

Question 92

SMOKING + CLOZAPINE (ANTI -CONVULSANT)

Answer 92

INDUCER - SMOKING IS AN INDUCER - DECREASED EFFECT OF CLOZAPINE

Question 93

ST. JOHNS WORT + CYCLOSPORINE (IMMUNOSUPRESSANT)

Answer 93

INDUCER - ST. JOHNS WORT IS AN INDUCER - IMMUNOSUPPRESANT WILL NOT TAKE EFFECT

Question 94

PHENYTOIN

Answer 94

INDUCE ITSELF

Question 95

in or out: urate

Answer 95

in

Question 96

in or out: acetic acid

Answer 96

out

Question 97

in or out: uric acid

Answer 97

out

Question 98

in or out: acetate

Answer 98

in

Question 99

↑ GFR= ? urinary drug excretion= ? Renal blood flow

Answer 99

↑ GFR= ↑ urinary drug excretion = ↑ renal blood flow (direct relationship)

Question 100

no active tubular secretion = ? drug effect = ? clearance

Answer 100

↑ drug effect (might cause toxicity) ↓ clearance there is a problem (impaired)

Question 101

↑ urine pH and amphetamine

Answer 101

amphetamine is a basic drug ↓ basic + basic = reabsorption clearance

Question 102

↓ urine pH and salicylate

Answer 102

acid + acid = reabsorption ↓ clearance

Question 103

↑ urine pH and salicylate

Answer 103

base + acid= ionization = excretion ↑ clearance

Question 104

truTruee or false: methylxanthine's affects renal blood flow

Answer 104

true - theophylline (1, 3 dimethylxanthine) - Caffeine (1,3,7 trimethylxanthine) - theobromine (1,7 dimethylxanthine)

Question 105

dimethylxanthine are competitive antagonist of what?

Answer 105

Adenosine receptor - adenosine receptor is a nucleotide that causes constriction. methyl xanthine antagonize these receptor causing now vasodilation and dilation of renal blood vessel

Question 106

probenecid inhibits secretion of penicillin

Answer 106

Probenecid (anti gout) flushes urate out of the body. Urate is a competitor of penicillin in Active renal secretion . it competitvely bind to organic an ion transporter, making it the first one to be excreted. On the other hand, penicillin stays longer in the body prolonging its effect

Question 107

cimetidine inhibits secretion of metformin and phenytoin

Answer 107

cimetidine blocks transport of 1. organic cat ion (transporter of metformin) 2. Multi drug and toxic compound extrusion causing intoxication. *Same concept on verapamil

Question 108

Acid or basic: Antacid

Answer 108

Basic Increase urine pH

Question 109

Acid or base: Sodium bicarbonate

Answer 109

Basic Increase urine pH

Question 110

Acid or base: Sodium bicarbonate

Answer 110

Base Increase urine pH

Question 111

Acid or base; Acetazolamide

Answer 111

Basic Increase urine pH

Question 112

Acid or base: Vit c

Answer 112

Acidic Decrease urine pH

Question 113

Acid or base: Ammonium chloride

Answer 113

Acidic Decrease urine pH

Question 114

Acid or base: Ammonium chloride

Answer 114

Acidic Decrease urine pH

Question 115

Acid or base:Methanamine

Answer 115

Base Decrease urine pH