Drug Interactions and Reactions

Question 1

Barbiturates, phenytoin, carbamazepine, rifampin, quinidine, griseofulvin.

Answer 1

Induction of P450 enzymes

Question 2

Cimetidine, Ketoconazole, INH, grapefruit, erythromycin, sulfonamides.

Answer 2

Inhibition of P-450 enzymes

Question 3

Benzos, amide anesthetics, metoprolol, propranolol, nefedipine, phenytoin, quinidine, theophylline, warfarin, barbiturates.

Answer 3

Metabolism by P-450 enzymes

Question 4

quinidine, cimetidine, amiodarone, CCB

Answer 4

↑ risk of digoxin toxicity

Question 5

Warfarin, ASA, phenytoin

Answer 5

Competition for albumin binding sites.

Question 6

Ibuprofen, quinidine, methyldopa, chemotherapeutic agents

Answer 6

Blood dyscrasias

Question 7

Sulfonamides, INH, ASA, ibuprofen, nitrofurantoin, primaquine, pyrimethamine, chloramphenicol.

Answer 7

Hemolysis in G6PD deficient patients

Question 8

Spironolactone, estrogens, digitalis, Cimetidine, chronic alcohol use, ketoconazole (Some Excellent Drugs Create Awesome Knockers)

Answer 8

Gynecomastia

Question 9

Ethosuximide, sulfonamides

Answer 9

Stevens Johnson syndrome

Question 10

Tetracycline, amiodarone, sulfonamides

Answer 10

Photosensitivity

Question 11

Procainamide, hydralazine, INH, penicillamine, chlorpromazine, methyldopa, quinidine.

Answer 11

Drug Induced SLE