Drug Metabolism Flashcards
1
Q
What is metabolism
A
Enzymatic processes that modify the chemical structure of a forgein/ strange molecule making it more water soluble so that it can be Easily secreted by the body
2
Q
Phase one reactions
A
Involve transformation of molecules such as oxidation, reduction and hydrolysis to make them more reactive
3
Q
Phase two reactions
A
Coupling the drug or metabolite with endogenous polar components , makes it more water soluble so that it can be excreted via the urine.
4
Q
Role of cytochrome p450 enzymes
A
They split molecular oxygen. One of the oxygen atoms is introduced into the drug ti produce metabolites and the other ends up in water.
Involves use of NADPH
5
Q
When an oxidation of carbon atoms happen in p2 metabolism
A
If the carbon is exposed or activiated
