Drug Metabolism

Question 1

What’s the purpose of Drug metabolism?

Answer 1

To convert compounds into polar molecules that can be easily excreted

Question 2

What is the primary goal of Phase 1 metabolism

Answer 2

To prepare the drug for phase 2 metabolism by creating sites for conjugation with endogenous molecules

Question 3

What enzymes are involved in Phase 1 metabolism

Answer 3

Cytochrome P450 enzymes

Question 4

What types of reactions occur in phase 1 metabolism?

Answer 4

Oxidation, Reduction and hydrolysis

Question 5

What’s the result of Phase 1 metabolism

Answer 5

Formation of active metabolites, inactive metabolites and toxic intermediates

Question 6

What does the formation of phase 1 metabolism depend on

Answer 6

nature of the drug and specific reactions involved

Question 7

What is phase 2 metabolism also known as ?

Answer 7

Conjugation

Question 8

What is Phase 2 metabolism

Answer 8

It’s the conjugation of phase 1 molecules with endogenous molecules to increase water solubility

Question 9

What are the 2 enzyme systems that take place in phase 1 reactions

Answer 9

Microsomal mixed Function oxidases
Non-cytochrome oxidising enzymes

Question 10

What are the CYP biotransformations?

Answer 10

Cytochrome P450 enzymes

Question 11

What reactions take place with CYP biotransformations?

Answer 11

Dealkylation
N and S-oxidations
Deamination
Dehalogenation
Aliphatic and aromatic hydroxylation