Drug Metabolism

Question 1

Two major ways of Drug Clearance

Answer 1

Renal Clearance

Drug metabolism

Question 2

Drug Metabolism

Answer 2

Bio transformation of drugs to more polar compounds that can be readily excreted

Question 3

How does Drug metabolism change PharmacoDynamics

Answer 3

Decreased efficacy or completely inactivated

Question 4

How does drug metabolism change PharmacoKinetics

Answer 4

Decreased Half-life and increased clearance

Question 5

How does drug metabolism change the toxic properties of a Drug

Answer 5

Usually it detoxifies

Sometimes more toxic like with Tylenol

Question 6

What is the primary location of drug metabolism

Answer 6

Liver

Question 7

Drug MEtabolism Reactions

Answer 7

Phase 1: adding of a polar group (Functionalization)

Phase 2: (Conjugation) of endogenous compounds to more polar conjugates

Question 8

First-Pass Effect

Answer 8

Following oral drug administration, the drug passes through the portal system first and some drug is lost there before ever reaching circulation.

Question 9

Glucoronidation

Answer 9

Quantitatively the most important phase 2 (conjugation) reaction

Question 10

Glutathione Conjugation

Answer 10

Major Detoxification pathway for drugs and carcinogens