Drug metabolism and elimination Flashcards
1
Q
What is pharmacokinetics
A
How the drug enters, is transported and eliminated
2
Q
What is pharmacodynamics
A
the effect the drug has on the body
3
Q
what are the main and secondary routes of excretion of drugs?
A
Main:
- kidneys/urine
- hepatobiliary system
- lungs
Secondary:
- milk
- sweat
4
Q
What is the role of cytochrome P450?
A
metabolise lipophilic/non-polar drugs into hydrophilic/polar compounds to allow excretion
5
Q
How can multiply drugs affect the activty of each other
A
The product of one drug reacting with a CYP450 may decrease or increase the expression of another CYP450
So the activty of the drug the affected CYP450 acts on could increase or decrease
6
Q
Where are CYP450 enzymes found?
A
endoplasmic reticulum
