Drug Reactions Flashcards

(3 cards)

1
Q

What are causes of Toxic Epidermal Necrolysis?

Symptoms?

Management?

A

Phenytoin
Sulphonamides
Allopurinol
NSAIDs
Penicillin
Carbamezapine

Systemically unwell, positive Nikolsky’s

Stop drug
Admit
Ciclosporin/cyclophosphamide
Plasmapheresis

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2
Q

Causes of Steven Johnsons Syndrome?

A

Phenytoin
Sulphonamides
Allopurinol
NSAIDs
Penicillin
Carbamezapine
COCP

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3
Q

Symptoms of Steven Johnsons Syndrome?

A

Maculopapular rash with target lesions developing into vesicles/bullae, positive Nikolsky’s, mucosal lesions, systemically unwell

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