Drug Reactions Flashcards
(3 cards)
1
Q
What are causes of Toxic Epidermal Necrolysis?
Symptoms?
Management?
A
Phenytoin
Sulphonamides
Allopurinol
NSAIDs
Penicillin
Carbamezapine
Systemically unwell, positive Nikolsky’s
Stop drug
Admit
Ciclosporin/cyclophosphamide
Plasmapheresis
2
Q
Causes of Steven Johnsons Syndrome?
A
Phenytoin
Sulphonamides
Allopurinol
NSAIDs
Penicillin
Carbamezapine
COCP
3
Q
Symptoms of Steven Johnsons Syndrome?
A
Maculopapular rash with target lesions developing into vesicles/bullae, positive Nikolsky’s, mucosal lesions, systemically unwell