drug reactions

Question 1

coronary vasospasm

Answer 1

cocaine, sumatriptan, ergot alkaloids, amphetamine

Question 2

cutaneous flushing

Answer 2

vancomycin, adenosine, niacin, Ca channel blockers

Question 3

dilated cardiomyopathy

Answer 3

doxorubicin, daunorubicin

Question 4

torsades de pointes

Answer 4

class III (e.g. sotalol) and class IA (e.g. quinidine) antiarrhythmics, macrolide antibiotics, antipsychotics (haloperidol), and TCAs

Question 5

adrenocortical insufficiency

Answer 5

abrupt glucocorticoid withdrawal

Question 6

hot flashes

Answer 6

tamoxifen, clomiphene (SERMs)

Question 7

hyperglycemia

Answer 7

tacrolimus, protease inhibitors, niacin, HCTZ, beta-blockers

Question 8

hypothyroidism

Answer 8

lithium, amiodarone, sulfonamides

Question 9

gynecomastia

Answer 9

ketoconazole, estrogens, spironolactone

Question 10

acute cholestatic hepatitis, jaundice

Answer 10

erythromycin

Question 11

diarrhea

Answer 11

metformin, erythromycin, colchicine, orlistat, acarbose

Question 12

focal to massive hepatic necrosis

Answer 12

halothane, valproic acid, acetaminophen

Question 13

hepatitis

Answer 13

Isoniazid

Question 14

pancreatitis

Answer 14

didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics

Question 15

pseudomembranous colitis

Answer 15

clindamycin, ampicillin, cephalosporins

Question 16

agranulocytosis

Answer 16

dapsone, clozapine, carbamazepine, colchicine, methimazole, PTU

Question 17

aplastic anemia

Answer 17

carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, PTU

Question 18

direct coombs + hemolytic anemia

Answer 18

methyldopa, penicillin

Question 19

grey baby syndrome

Answer 19

chloramphenicol

Question 20

hemolysis in G6PD deficiency

Answer 20

INH, Sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin, fava beans

Question 21

megaloblastic anemia

Answer 21

phenytoin, methotrexate, sulfa drugs

Question 22

thrombocytopenia

Answer 22

heparin, cimetidine

Question 23

thrombotic complications

Answer 23

OCPs (estrogens)

Question 24

fat redistribution

Answer 24

protease inhibitors, steroids

Question 25

gingival hyperplasia

Answer 25

phenytoin, verapamil, cyclosporine, nifedipine

Question 26

hyperuricemia (gout)

Answer 26

pyrazinamide, thiazides, furosemide, niacin, cyclosporine

Question 27

myopathy

Answer 27

Fibrates, niacin, colchicine, hydroxychloroquine, IFN-alpha, penicillamine, statins, steroids

Question 28

osteoporosis

Answer 28

corticosteroids, heparin

Question 29

photosensitivity

Answer 29

sulfonamides, amiodarone, tetracyclines, 5-FU

Question 30

stevens-Johnson

Answer 30

anti epileptic drugs, allopurinol, sulfa drugs, penicillin

Question 31

SLE-like syndrome

Answer 31

sulfa-drugs, hydrazine, INH, procainamide,

Question 32

teeth discoloration

Answer 32

tetracyclines

Question 33

tendonitis, rupture

Answer 33

fluoroquinolones

Question 34

cinchonism (dizziness, HA, vision changes, tinnitus)

Answer 34

quinidine, quinine

Question 35

parkinson-like syndrome

Answer 35

antipsychotics, reserpine, metoclopramide

Question 36

seizures

Answer 36

isoniazid (due to B6 deficiency), bupropion, imipenem/cilastatin, tramadol, enflurane, metoclopramide

Question 37

tardive dyskinesia

Answer 37

antipsychotics, metoclopramide

Question 38

diabetes insipidus

Answer 38

lithium, demeclocylcine

Question 39

fanconi syndrome

Answer 39

expired tetracycline

Question 40

hemorrhagic cystitis

Answer 40

cyclophosphamide, ifosfamide

Question 41

interstitial nephritis

Answer 41

methicillin, NSAIDs, furosemide

Question 42

SIADH

Answer 42

carbamazepine, cyclophosphamide, SSRIs

Question 43

cough

Answer 43

ACE inhibitors

Question 44

pulmonary fibrosis

Answer 44

bleomycin, amiodarone, busulfan, methotrexate

Question 45

disulfiram- like reactions

Answer 45

disulfiram, metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st gen. sulfonylureas

Question 46

nephrotoxicity/ototoxicity

Answer 46

aminoglycosides, vancomycin, loop diuretics, cisplatin