Drug reactions

Question 1

Coronary vasospasm

Answer 1

Cocaine, sumatriptan, ergot alkaloids

Question 2

Cutaneous flushing

Answer 2

Vancomycin, Adenosine, Niacin, CCBs (“VANC”)

Question 3

Dilated cardiomyopathy

Answer 3

Doxorubicin, Daunorubicin

Question 4

Torsades de pointes

Answer 4

Class III (sotalol) and class IA (quinidine) anti-arrhythmics, QPIDDS - Quinidine, Procrainimide, Ibutilide, Dofetilide, Disopyramide, Sotalol

Question 5

Agranulocytosis

Answer 5

Clozapine, Carbamazepine, Colchicine, Propylthiouracil (PTU), Methimazole, Dapsone, “Agranulocytosis Could Certainly Cause Pretty Major Damage,” Tx by stopping drug and giving G-CSF

Question 6

Aplastic anemia

Answer 6

Chloramphenicol, benzene, NSAIDs, Propylthiouracil (PTU), Methimazole

Question 7

Direct Coombs-positive hemolytic anemia

Answer 7

Methyldopa, PCN

Question 8

Gray baby syndrome

Answer 8

Chloramphenicol

Question 9

Hemolysis in G6PD-deficient patients

Answer 9

Isoniazid (INH), Sulfonamides, Primaquine, ASA, Ibuprofen, Nitrofurantoin; “Hemolysis IS PAIN”

Question 10

MegaloBLASTic anemia

Answer 10

Phenytoin, MTX, Sulfa drugs; “Having a BLAST with PMS”

Question 11

Thrombotic complications

Answer 11

OCPs (i.e. estrogens)

Question 12

Cough

Answer 12

ACE-inhibitors

Question 13

Pulmonary fibrosis

Answer 13

BLeomycin, Amiodarone, Busulfan; “It’s hard to BLAB when you have pulmonary fibrosis”

Question 14

Acute cholestatic hepatitis, jaundice

Answer 14

Erythromycin

Question 15

Focal to massive hepatic necrosis

Answer 15

Halothane, Aanita phalloides (found in poisonous mushrooms - inhibit RNA polymerase II, which dec mRNA synthesis), Valproic acid, Acetaminophen; “Liver ‘HAVAc’”

Question 16

Hepatitis

Answer 16

INH, Pyrazinamide

Question 17

Pseudomembranous colitis

Answer 17

Clindamycin, ampicillin

Question 18

Adrenocortical insufficiency

Answer 18

Glucocorticoid withdrawal (HPA suppression)

Question 19

Gynecomastia

Answer 19

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole, marajauna, heroin; “Some Drugs Create Awesome Knockers”

Question 20

Hot flashes

Answer 20

Tamoxifen, clomiphene

Question 21

Hyperglycemia

Answer 21

Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

Question 22

Hypothyroidism

Answer 22

Lithium, amiodarone, sulfonamides

Question 23

Fat redistribution

Answer 23

Glucocorticoids, protease inhibitors

Question 24

Gingival hyperplasia

Answer 24

Phenytoin, verapamil, cyclosporine

Question 25

Gout

Answer 25

Furosemide, thiazides, niacin, cyclosporine, pyrazinamide

Question 26

Myopathies

Answer 26

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Ifn-alpha, Penicillamine, Statins, Glucocorticoids; Fish N CHIPS Give you myopathies

Question 27

Osteoporosis

Answer 27

Corticosteroids, heparin

Question 28

Photosensitivity

Answer 28

Sulfonamides, Amiodarone, Tetracycline; "SAT for a photo"

Question 29

Rash (Stevens-Johnson syndrome)

Answer 29

PCN, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbitol; "bad rash after a PEC SLAPP" (ECLPP are seizure drugs)

Question 30

SLE-like syndrome

Answer 30

Sulfonamides, Hydralazine, INH, Procainamide, Phenytoin; "SHIPP" linked to drugs that are metabolized via N-acetylation in liver (Phase 2)

Question 31

Teeth (kids)

Answer 31

Tetracyclines

Question 32

Tendonitis, tendon rupture, and cartilage damage

Answer 32

Fluoroquinalones

Question 33

Diabetes Insipidus

Answer 33

Lithium, demeclocycline

Question 34

Fanconi's syndrome

Answer 34

Expired tetracycline

Question 35

Hemorrhagic cystitis

Answer 35

Cyclophosphamide, ifosfamide (prevent by co-admin with mesna)

Question 36

Interstitial nephritis

Answer 36

Methicillin, NSAIDs, furosemide

Question 37

SIADH

Answer 37

Carbamazepine, cyclophosphamide

Question 38

Cinchonism

Answer 38

Quinidine, quinine

Question 39

Parkinson-like syndromes

Answer 39

Anti-psychotics, reserpine, metoclopramide

Question 40

Seizures

Answer 40

INH, Buproprion, Impipenem/cilastatin, Tramadol, Enflurane, Metoclopramide; "with seizures, I BITE My tongue"

Question 41

Tardive dyskinesia

Answer 41

Anti-psychotics

Question 42

Anti-muscarinic

Answer 42

Atropine, TCAs, H1-blockers, neuroleptics

Question 43

Disulfuram-like reaction

Answer 43

Metronidazole, certain cephalosporins, procarbazine, 1st-gen sulfonylureas

Question 44

Nephrotoxicity/Ototoxicity

Answer 44

Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin

Question 45

Abx to avoid in pregnancy

Answer 45

Countless SAFe Moms Take Really Good Care; Clarithromycin (embryotoxic), Sulfonamides (kernicterus), Aminoglycosides (ototoxicity), Flouroquinalones (cartilage damage), Metronidazole (mutagenesis), Tetracyclines; (discolored teeth/inhibition of bone growth), Ribavirin (teratogenic), Griseofulvin (teratogenic), Chloramphenicol ("gray baby" sxr)

Question 46

Serotonin syndrome

Answer 46

SSRIs, SNRIs, MAOIs, TCAs, Tramadol, Odansteron, Linezolid,Triptans