Immuno

Question 1

HLA A3

Answer 1

Hemochromatosis

Question 2

HLA B27

Answer 2

PAIR - Psoriasis, Ankylosing spondylitis, Inflammatory bowel disease, Reiter’s syndrome

Question 3

HLA DQ2.DQ8

Answer 3

Celiac disease

Question 4

HLA DR2

Answer 4

MS, hay fever, SLE, Goodpasture’s

Question 5

HLA DR3

Answer 5

DM Type I, Graves’ disease

Question 6

HLA DR4

Answer 6

DM Type I, RA

Question 7

HLA DR5

Answer 7

Pernicious anemia -> B12 deficiency, Hashimoto’s Thyroiditis

Question 8

Upper limb/lateral breast

Answer 8

axillary nodes

Question 9

Stomach

Answer 9

Celiac nodes

Question 10

Dudoenum/Jejunum

Answer 10

SMA nodes

Question 11

Sigmoid colon

Answer 11

Colic -> IMA nodes

Question 12

Rectum (lower) and anal canal (above pectinate line)

Answer 12

Internal iliac nodes

Question 13

Anal canal (below pectinate line)

Answer 13

Superficial inguinal nodes

Question 14

Testes/ovaries

Answer 14

Paraortic nodes

Question 15

Scrotum

Answer 15

Superficial inguinal nodes

Question 16

Thigh (superficial)

Answer 16

Superficial inguinal nodes

Question 17

Lateral side of dorsum of foot

Answer 17

Popliteal nodes

Question 18

C3b

Answer 18

opsonization

Question 19

C3a, C5a

Answer 19

Anaphylaxis

Question 20

C5a

Answer 20

neutrophil chemotaxis

Question 21

C5b-C9

Answer 21

cytolysis by MAC

Question 22

CD16, CD56

Answer 22

NK cells

Question 23

CD25, CD3, CD4

Answer 23

Regulatory T cells

Question 24

Severe, recurrent pyogenic sinus and respiratory tract infections (S. pneumo, H. influenzae), Inc susceptibility to Type III hypersensitivity (esp. gloerulonephritis)

Answer 24

C3 deficiency

Question 25

Defect in BTK (tyrosine kinase) -> no B cell maturation; recurrent bacterial infections after 6 months; dec immunoglobulins of all classes

Answer 25

X-linked (Bruton's) agammaglobulinemia

Question 26

Most common primary immunodeficiency; False-positve beta-hCG due to presence of heterophile Ab; sinopulmonary infections

Answer 26

Selective IgA deficiency

Question 27

Tetany, recurrent vital/fungal infection, congenital and heart and great vessel disease

Answer 27

Thymic aplasia (DiGeorge)

Question 28

Dec TH1 response; disseminated mycobacterial infections, dec IFN-gamma

Answer 28

IL-12 deficiency

Question 29

Eczema, reccurrent staph abscesses, coarse facial features

Answer 29

Hyper-IgE (Job's) - inability of neutrophils to respond to chemotactic stimuli due to TH1 cells failing to produce IFN-gamma

Question 30

Defective IL-2 receptor; adenosine deaminase deficiency; absence of thypic shadow

Answer 30

SCID

Question 31

Failure to thrive, chronic diarrhea, recurrent infections (candida, RSV, VZV, HSV, measles, flu, parainfluenza)

Answer 31

SCID

Question 32

Defects in ATM gene which codes for DNA repair enzymes; cerebellar defects, spider angiomas; IgA deficiency; Inc AFP

Answer 32

Ataxia-Telengectasia

Question 33

Usually defective CD40L on T cells -> inability to class switch; Inc IgM, dec IgG/IgA/IgE; X-linked

Answer 33

Hyper-IgM syndrome

Question 34

WAS gene; T cells unable to reorganize actin cytoskeleton; Inc IgA, dec IgM; X-linked

Answer 34

Wiskott-Aldrich syndrome

Question 35

Thrombocytopenic purpura, Infections, Ezema

Answer 35

Wiskott-Aldrich syndrome

Question 36

Defect in LFA-1 integrin (CD18); recurrent bacterial infections w/ absent pus formationl delayed separation of umbilical cord; neutrophilia

Answer 36

Leukocyte adhesion deficiency (type 1) - neutrophils fail to respond to chemotactic stimuli

Question 37

Defect in lysosomal trafficking regulator gene (LYST); microtubule dysfunction; giant granules in neutrophihls

Answer 37

Chediak-Higashi syndrome

Question 38

Partial albinism, neurological defects, recurrent pyogenic infections

Answer 38

Chediak-Higashi syndrome

Question 39

Lack of NADPH oxidase -> dec reactive oxygen species; inc susceptibility to catalase-positive organisms (S. aureus, E. Coli, Aspergillus, Pseudomonas, Nocardia, Serratia); Abnormal dihydrorhodamine (DHR) flow cytometry test; Negative nitroblue tetrazolium dye test; X-linked

Answer 39

Chronic granulomatous disease

Question 40

CD 14, CD 40, MHC II, B7

Answer 40

Macrophages

Question 41

CD19, CD20, CD21, MHC II, B7

Answer 41

B-cells

Question 42

CD4, CD40L

Answer 42

Helper T cells

Question 43

CD8

Answer 43

Cytotoxic T cells