Drug response

Question 1

EC50 is > or < than Kd

Answer 1

EC50 < kd; we don’t have to occupy all the receptors to get a response

Question 2

drug that is the most potent

Answer 2

has the highest affinity

Question 3

Emax

Answer 3

efficacy

Question 4

Ec50 (concentration) or ED50 (Dose)

Answer 4

affinity and potency

Question 5

competitive inhibitor

Answer 5

shift to the right

Question 6

noncompetitive antagonist or partial agonist

Answer 6

Max. efficacy not reached

Question 7

LD50

Answer 7

lethal dose

Question 8

drugs that pass most readily through cell membranes

Answer 8

non-ionized

Question 9

for weak acids, the protonated form is _______

Answer 9

non-ionized

Question 10

for weak bases, the protonated form is ______

Answer 10

ionized

Question 11

what determines the amount of ionization of a drug?

Answer 11

pH

Question 12

Blood pH

Answer 12

7.4

Question 13

ionized at low pH

Answer 13

base

Question 14

ionized at high pH

Answer 14

acid

Question 15

is it good at binding a receptor?

Answer 15

affinity

Question 16

when it binds, does it produce a strong response?

Answer 16

efficacy

Question 17

more active receptors

Answer 17

agonist

Question 18

lower efficacy agonist

Answer 18

partial agonist

Question 19

diminishes effect of agonist. Can be competitive or non-competitive

Answer 19

antagonist

Question 20

concentration that give the half of max

Answer 20

EC50

Question 21

adding a competitive antagonist _______ EC50

Answer 21

increases; it takes more agonist to achieve the same response

Question 22

adding noncompetitive antagonist _______ receptors

EC50 is _______

Answer 22

inactivates; you can no longer reach as high of a response

EC50 is the same as before

Question 23

dose that causes desired effect in half of the population

Answer 23

ED50

Question 24

dose that causes death in half of the population

Answer 24

LD50

Question 25

LD50/ ED50

Answer 25

therapeutic index

Question 26

can charged drugs cross the membrane? what happens to them?

Answer 26

they have some trouble crossing and if they become trapped

Question 27

acidic drugs can become charged by

Answer 27

losing a proton

Question 28

basic drugs can become charged by

Answer 28

gaining a proton

Question 29

acidic charge

Answer 29

HA/ A = 10^ pka-ph

Question 30

basic charge

Answer 30

B/ BH = 10^ pH-pka