Pharmokinetics Flashcards
Exam 1 (29 cards)
can some clearance occur in the active upstroke absorption?
YES
where is most of the drug being absorbed?
upper GI tract
pre-systemic extraction–> some of the drug is absorbed before reaching the systemic circulation
first-pass
fraction of drug absorbed systemically after extravascular vs intravascular administration
systemic availability
low bioavalability
- first pass effect
2. poor absorption
peak plasma concentration
Cmax
time of peak concentration
Tmax
area under the plasma concentration curve
AUC
allows us to make assumptions in the body about how the drug is acting in the body
volume of distribution
Dose/ [plasma]
volume of distribution
F
bioavailability
one time dose to achieve effects faster
loading dose
total volume of plasma from which drug is completely removed per unit time
clearance
steady state concentration
the amount of drug being absorbed vs the amount of drug being cleared
blood flow to clearing organ
Q
extraction ratio of that organ
E
why with an oral dose, the drug does not appear immediately in the blood?
lag time
bioavailability with oral dose
decreases
assume dose spreads across a volume at a constant concentration
one-compartment model
dose spreads to certain areas first before spreading throughout body
two-compartment model
getting rid of a certain amount of drug in all of the volume
elimination
getting rid of all of the drug in a certain amount of volume
clearance
clearance is in units of
volume / time
if we want to consider the fraction of total drug volume that we have cleared we use
k= clearance / Vd
