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Pharma > DRUG SAMPLES 3 > Flashcards

DRUG SAMPLES 3 Flashcards

1
Q

Mechanism of action of Dimenhydrinate (RAMAMINE)?

A

Competitive H1 blocker (1St generation H1 receptor antagonist)

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2
Q

Similar drug as Dimenhydrinate (RAMAMINE)?

A

Chlorophenhydramine

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3
Q

Therapeutic three uses of Dimenhydrinate (RAMAMINE)? M.A.P

A

1- Motion sickness
2- Allergic disorders
3- Preanesthetic medication

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4
Q

Three main Adverse Effects of Dimenhydrinate (RAMAMINE)?
A.P.S.G

A

1- Atropine like action
2- Postural hypotension
3- Sedation
4- GIT disturbance (nausea, vomiting)

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5
Q

Uses of Dimenhydrinate (RAMAMINE)? in dentistry

A

1- Allergy
2- Preanesthetic medication

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6
Q

Mechanism of action of
Loratadine ( Claritine ) ?

A

Competitive H1 blocker (2nd generation)

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7
Q

Similar drug as Loratadine ( Claritine )?
Fexo/ ceti

A

Fexofenadine , cetirizine

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8
Q

three therapeutic uses of
Loratadine (Claritine)?

A

1/ Allergic disease
2/ Anaphylactic shock with adrenaline

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9
Q

Uses of Loratadine (Claritine) in dentistry?

A

1/ Pre-anesthetic
2/ Anaphylactic shock with adrenaline

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10
Q

Advantages of Loratadine (Claritine) ?

Less/longer/No

A

1- less sedation
2- Longer duration
3- No atropine side effects

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10
Q

Mechanism of action of
Ciprofloxacin (CIPROXIN / CIPROCIN)?
Iso 2,4

A

Bactericidal inhibit isomerase 2 in Gm–ve & isomerase 4 in Gm+ve

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10
Q

Antimicrobial activity of Ciprofloxacin (CIPROXIN / CIPROCIN)?
بتاععععع الباكتيريا

A

Bactericidal broad spectrum

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11
Q

Three Main Therapeutic uses of Ciprofloxacin (CIPROXIN / CIPROCIN)?

T.R.U.G

A

1- ttt of UTI
2- ttt of Typhoid
3- ttt of gonorrhea
4- ttt of Respiratory tract infection

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12
Q

Three Main Adverse Effects of Ciprofloxacin (CIPROXIN / CIPROCIN)?
بيكره ال bone واي حاجة تبعها

A

-Arthropathic damage of bone cartilage drug
-drug interaction

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13
Q

The use of Ciprofloxacin (CIPROXIN / CIPROCIN) in children?
عدو ال bone وقرايب الbone

A

Contraindicated in Children less than 18
damage of growing cartilage and bone &joint damage

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14
Q

Uses of Ciprofloxacin (CIPROXIN / CIPROCIN) in Dentistry?

ثبروفلوكثاثين بيعالج اللثه

A

Management of refractory periodontitis

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15
Q

Mechanism of action of Amoxicillin + clavulanic acid (AUGMENTIN)?

A

Inhibit cell wall synthesis

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16
Q

Similar drug as Amoxicillin + clavulanic acid (AUGMENTIN)?

A-B-C/ P-P

A

Ampicillin – pivampicillin- bacampicillin-
Cloxacillin-penicillin

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17
Q

Therapeutic uses of Amoxicillin + clavulanic acid (AUGMENTIN)?

BTW /TGD

A

1/ Broad spectrum Antibiotics
2/ Tonsillitis hURT infection
3/ wound sepsis-meningococcal infections
4/ gonorrhea-tetanus-diphtheria.

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18
Q

Side effects of Amoxicillin + clavulanic acid (AUGMENTIN)?

A.u.G.ment.IN

A

1- Allergic reactions
2- GIT disturbance and superinfection
3- CNS irritation if intrathecal

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19
Q

Value of combination of Amoxicillin + clavulanic acid (AUGMENTIN)?

A

Clavulanic acid is beta-lactamase inhibitor protect amoxicillin from inactivation by B-lactamases secreted by some bacteria

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20
Q

Uses of Amoxicillin + clavulanic acid (AUGMENTIN) in Dentistry?

A
  • ttt of facial and dental infection
  • ttt infection by G+ve and G-ve anerobic
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21
Q

Mechanism of action of
Gentamicin (GARAMYCIN)?

A

Inhibit the protein synthesis of bacteria

22
Q

Similar drugs as Gentamicin (GARAMYCIN)?

Strept/tobra/neo/amika

A

Streptomycin-amikacin-
Tobramycin-neomycin

23
Q

Therapeutic uses of Gentamicin (GARAMYCIN)?

G.E.n.T.a.M.icin

A
  • Severe serious gram-ve infections : - -Pneumonia, UTI, osteomyelitis
  • Pseudomonas infection
  • Enterobacter endocarditis
  • Methicillin-resistant staph (MRSA)
  • Topically&raquo_space;> burns, wounds &skin lesions
24
Q

Side effects of Gentamicin (GARAMYCIN)?

2 toxicity / relax

اهدى انا بس هسممك مش هعمل حاجة

A
  • ototoxicity(damage 8th cranial nerve)
  • Reversible nephrotoxicity
  • Skeletal muscle relaxation
  • Allergy
  • GIT upset
25
Q

Spectrum of activity of Gentamicin (GARAMYCIN)?

A

Narrow spectrum (G –ve aerobic bacteria)

26
Q

Uses of Gentamicin (GARAMYCIN) in Dentistry?

جينتامايسن جوووووو GO
G > Gentamicin
O > O…

A

Orofacial infections

27
Q

Mechanism of action of Doxycycline (VIBRAMYCIN) ?

A

Inhibit protein synthesis of bacteria (bacteriostatic)

Gentamicin & Doxy
بيكرهوا يلعبوا مع البروتين

28
Q

Similar drug as Doxycycline (VIBRAMYCIN) ?

A

Tetracycline

29
Q

Therapeutic uses of Doxycycline (VIBRAMYCIN) ?

بيعالج بالبرجر burger 🍔
A> خبز البرجر
C> …
A> …
R> خبز البرجر

A

1- Atypical infection
2- ttt of cholera
3- ttt of Acne
4- Rickettsia infection

30
Q

Side effects of Doxycycline (VIBRAMYCIN) ?

A

Teratogenic in pregnant

31
Q

The use of Doxycycline (VIBRAMYCIN) in children?

A
  • ca+2 deposition in bones& teeth
  • Not used in child less than 8years due to permanent discoloration of teeth
32
Q

Uses of Doxycycline (VIBRAMYCIN) in Dentistry?

A

ttt of dental infection caused by susceptible organism

33
Q

Mechanism of action of Azithromycin (ZITHROMAX)?

A

Reversible inhibition of protein synthesis in bacteria, bactericidal in large dose

Gentamicin/Doxy/Azi
ال 3 بيكرهوا البروتين

34
Q

Similar drugs as Azithromycin (ZITHROMAX)?
Ery/Spi

A

Erythromycin- Spiramycin

35
Q

Therapeutic uses of Azithromycin (ZITHROMAX)?

DWT PC

A
  • Diphtheria
  • Whooping cough
  • Pneumonia caused by mycoplasma and legionella
  • Chlamydial infection
  • Topically in Acne vulgaris
36
Q

Side effects of Azithromycin (ZITHROMAX)?

A
  • GIT disturbance
  • Allergy (cholestatic jaundice)
37
Q

Three advantage of Azithromycin (ZITHROMAX) over erythromycin?

A
  • Longer t1l2
  • Less GIT side effects
  • More acid labile
38
Q

Uses of Azithromycin (ZITHROMAX) in Dentistry?
وقايه / G-ve

A
  • ttt of orofacial infection caused by anaerobic G –ve
  • Prophylaxis of endocarditis after tooth extraction
39
Q

Mechanism of action of Metronidazole (Flagyl)?

A

It is a prodrug within the sensitive protozoal cells and anaerobic bacteria the nitro group of metronidazole is chemically reduced leading to formation of cytotoxic products that destroys the cell.

40
Q

Similar drug as Metronidazole (Flagyl)?

A

Tinidazole

41
Q

Therapeutic uses of Metronidazole (Flagyl)?

3 > iasis
Hp/Clo

A

Amebiasis — trichomoniasis — giardiasis
Anaerobic bacterial infection as H-pylori and clostridium deficel

42
Q

Side effects of Metronidazole (Flagyl)?

DHD/V²PN

A

1- Headache
2- Dizziness - Diarrhea
3- Vomiting -Nausea
4- Vertigo- Paresthesia

43
Q

Uses of Metronidazole (Flagyl) in Dentistry?

MetroAna

A

Anaerobic infection in oral cavity

44
Q

Mechanism of action of Fluconazole (DIFLUCAN)?

F>fungal

A

They decrease ergosterol synthesis which is essential for synthesis of cell membrane by inhibition of fungal cytochrome p450

45
Q

Advantages of Fluconazole (DIFLUCAN) over ketoconazole?

A

-Well absorbed orally
-Not affected by acid and food
-Can cross BBB
-Less endocrine SE

Flu > flow > well absorbed orally
ضد الكسر مش بيتاثر بال acid وال food
بيعمل اللي عايزه BBB
في حاله من غير اذيه لحد

46
Q

Therapeutic uses of Fluconazole (DIFLUCAN)?

Flu>F > 2 FUNGAL

A
  • ttt of mucocutaneous fungal infection
  • ttt of systemic fugal infection
47
Q

Side effects of Fluconazole (DIFLUCAN)?
Hyper/ Hepatic / GIT

A
  • Hypersensitivity
  • Hepatic dysfunction
  • GIT disturbance
48
Q

Uses of Fluconazole (DIFLUCAN) in Dentistry?

A

ttt of oropharyngeal candidiasis

49
Q

Mechanism of action of Dexamethasone (Fortecortin) ?

A

Bind to nuclear receptor&raquo_space;> complex»> enter nucleus&raquo_space;> bind to glucocorticoid receptor element&raquo_space;>modify gene transcription.
(Anti-inflammatory and immunosuppressive)

50
Q

Similar drug as Dexamethasone (Fortecortin)?

A

Hydrocortisone

51
Q

Therapeutic uses of Dexamethasone (Fortecortin)?

A

1- brain edema.
2- ttt of arthritis
3- maturation of fetal lung
4- ITP (immune thrombocytopenia)
5- Dexamethasone suppression test

52
Q

Side effects of Dexamethasone (Fortecortin)?

A

1-osteoporosis.
3- moon face.
2- hyperglycemia.
4- truncal obesity.
5- cataract & glaucoma

53
Q

contraindication of Dexamethasone (Fortecortin)?

A

Herpes simplex keratitis

54
Q

Uses of Dexamethasone (Fortecortin) in Dentistry?

A

Orofacial autoimmune disease

Pharma (20 decks)

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