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Flashcards in Drug Table Deck (40):
1

2 MAO-B selective Inhibitors:

-Selegiline
-Rasagiline

2

MAOI + ___ --> Hypertensive Crisis
MAOI + ___ --> Serotonin Syndrome

-Tyramine
-SSRI

3

2 COMT inhibitors:

-Entacapone
-Tolcapone

4

1st line treatment for Parkinson's (Combo)

Levodopa + Carbidopa (limit peripheral conversion)

5

Only drug for Huntington's Chorea
Mechanism?

Tetrabenzine
-prevent monoamine release

6

What class can cause TD, EPS, NMS?

Antipsychotics

7

Drug with most metabolic risk of all antipsychotics:

Clozapine

8

Common mechanism of all antipsychotics

D2 receptor antagonism

9

Additional mechanism of 2nd gen 'Atypical' antipsychotics:

5HT2a receptor antagonism

10

2 Groups of 2nd gen antipsychotics and their side effects:

'Pines' --> sedation
'Dones' --> EPS

11

What is EPS:

Extrapyramidal symptoms: drug-induced movement disorders
1. Dystonia: continuous spasm, muscle contractions
2. Akathisia: motor restlesness
3. Parkinsonism: rigidity, bradykinesia, tremor
4. Tardive dyskinesia: jerky, irregular

12

Drug used to diagnose myasthenia gravis

Edrophonium

13

Drug used to confirm Horner's Syndrome

Cocaine

14

Prostaglandin analog mechanism of action:

Increase uveoscleral outflow

15

Carbonic anhydrase inhibitor mechanism of action:

Reduce aquous humor production

16

Lithium uses

-Anti-manic
-Mood-stabilizing (bipolar)
-Long-term Cluster headache prevention

17

Antidote for methanol and ethylene glycol poisoning

Fomepizole - blocks alcohol dehydrogenase

18

Hallucinogen mechanism of action:

5HT2a receptor agonist

19

Fluoxetine and Paroxetine side effects not shared w/ other SSRIs:

Potent P450 inhibition

20

2 Atypical Antidepressants and their mechanisms:

Buproprion: NDRI
Mirtazapine: 5HT2a antagonist, SRI

21

2 Major active metabolites of morphine

M6 (more potent/active)
M3 (little affinity)

22

3 Common opioid side effects:

1. Miosis
2. Constipation
3. Respiratory depression

23

Opioid mechanism of action:

Mu- opioid receptor agonist

24

Opiods w/ GI effect:

Loperamide
Diphenoxylate

25

Synthetic codeine analog:

Tramadol

26

Opioid antagonists:

Naloxone
Naltrexone

27

Benzodiazepine mechanism of action:

GABAa agonist: binding between a1 and y2 subunits

28

Benzo w/ shortest half-life:

Midazolam, 1.9 hours

29

Benzo used to prevent alcohol withdrawl symptoms:

Lorazepam

30

Benzo used to induce sleep:

Triazolam

31

Benzodiazepine antidote:

Flumazenil

32

2 Barbituate drugs:

Thiopental
Phenobarbitol

33

Anxiolytic without marked sedation

Busiprone

34

[Benzodiazepines/Barbituates] have life-threatening withdrawal symptoms

Barbituates (and alcohol)

35

Nitrous Oxide mechanism

NMDA receptor antagonist

36

What is Propofol infusion syndrome?

IV infusion for several days -->
1. Metabolic acidosis
2. Rhabdomyolysis
3. Heart and renal failure
4. Lower BP
5. Bradycardia
6. Death

37

Rocuronium mechanism and antidote

Competitive ACh blocker (non-depolarizing)

Sugammadex - complexes w/ rocuronium

38

What is Hofman elimination?

Spontaneous, non-enzymatic degradation

39

2 Types of local anesthetics

-'Esters'
-'Amides'

40

Local anesthetic with highest cardiac toxicity potential

Bupivicaine