Drug Targets Flashcards
(22 cards)
What are the routes of drug administration
Enteral (Oral) Parenteral (Non GIT, IM, IV, SC) Inhaled ICS Topical cream Rectal
What is the most common drug target
G Protein Coupled Receptor
- Agonist
- Antagonist
What is the difference in affinity and efficacy between antagonist and agonist drugs
Agonist = Full affinity and efficacy Anatgonist = Full affinity and ZERO Efficacy
What is affinity
How well it binds
What is efficacy
How well the receptor activates
What is Potency
How much drug needed to elicit a response in the body
What is the difference in potency and efficacy between competitive and non competitive antagonists
Competitive = decrease potency but same efficacy
Non Comp = Decrease potency and efficacy
What are allosteric modulators
Change normal ligand binding
What is a non selective beta blocker
Propanolol
What is a selective beta blocker
Atenolol/Bisoprolol
What is a non selective beta agonist
Isoprenaline (Increases contractility and vasoconstriction)
What is a selective Beta2 agonist
SAB2A (Bronchodilation)
What is an NSAID
COX-1 Inhibitor (Prevent arachidonic acid becoming prostaglandin)
SE = Ulcers
What is an ACE-I
Inhibits Angiotensin 1 into 2
SE =Hyperkalemia, dry cough and teratogenic
What is a PPI
Irreversible inhibition of H-K ATPase pump to lower gastric pH
What is a loop diuretic
Inhibit NKCC2 Symporter in ascending loop of henle
What is a thiazide diuretic
Inhibit NaCl co transporter in DCT
What is Spiranolactone
K sparing aldosterone inhibitor
What is a CCB
Decreases vasoconstriction and contractility by inhibiting Calcium Influx
How does Lidocaine (Anaethesia) work
Block Na voltage gated channels = low sodium influx = no ABP
What is meant by a specific drug
Acts on certain target
What is meant by selective drugs
Acts on target subtype (general)
