DRUG1USE Flashcards
(143 cards)
1
Q
-Cimetidine (OAT)
A
Increase circulating drug level
2
Q
-Proadifen (OCT)
A
Increase circulating drug level
3
Q
-Probenecid
A
Increase circulating drug level
4
Q
- Ethanol
A
Decrease circulating drug level
5
Q
- Phenobarbital
A
Decrease circulating drug level
6
Q
Bethanechol
A
Stimulate smooth muscle post-operatively – increased GI motility, sphincters relax, stimulate secretions
7
Q
Carbachol
A
Wide-angle glaucoma (constrict ciliary muscle)
8
Q
Methacholine
A
Slow heart in severe tachycardia
9
Q
Pilocarpine
A
Glaucoma (short term treatment of acute angle-closure), treat dry mouth
10
Q
Ambenonium
A
Myasthenia gravis
11
Q
Edrophonium
A
Myasthenia gravis, ileus, arrhythmias, reversal of neuromuscular blockade (short)
12
Q
Neostigmine
A
Myasthenia gravis (reference therapeutic agent), ileus, reversal of neuromuscular blockade (long)
13
Q
Physostigmine
A
Glaucoma – given for short term treatment of acute angle-closure
14
Q
Pyridostigmine
A
Myasthenia gravis
15
Q
- Diisopropyl-fluorophosphate
A
None
16
Q
- Echothiopate
A
Echothiopate for glaucoma
17
Q
- Carbaryl
A
None
18
Q
- Malathion
A
Lice
19
Q
- Parathion
A
None
20
Q
- Tetraethyl-pyrophosphate
A
None
21
Q
- Sarin
A
none
22
Q
- Soman
A
none
23
Q
Pralidoxime
A
Step 2 following OP intoxication
24
Q
Atropine
A
OP and cholinergic agonist toxicity, elicit tachycardia following brady from MI, anti-parkinson, relieves urinary incontinence, mydriasis (7-10 days), anti-motion sickness
25
Homatropine
Mostly used for eye effects (topical agent) – mydriasis (1-3 days)
26
Scopolamine
Anti-motion sickness, amnesia (pre-anesthetic), mydriasis (3-7 days), induction of amnesia
27
Methscopolamine
Mostly GI diseases
28
Trihexyphenidyl
Decrease uncoordinated movement and excess salivation for parkinsons
29
Tropicamide
Mostly used as topical ocular treatment – mydriasis (6 hours)
30
Cyclopentolate
Mydriasis – 1 day
31
Ipratropium
Topical - minimizes mucociliary clearance issues (pts with airway problems – COPD)
32
Tiotropium
Topical - targets bronchodilation and minimizes mucociliary clearance issues
33
- Darifenacin
Urinary urgency, bladder spasms
34
- Solifenacin
Urinary urgency, bladder spasms
35
- Tolterodine
Urinary urgency, bladder spasms
36
Mecamylamine
Improve absorption from GI tract (oral – 12 hours), adjunct therapy for hypertension and peripheral vascular disease
37
Trimethaphan
IV infusion use (lasts minutes), adjunct therapy for hypertension and peripheral vascular disease, short-acting IV to minimize blood loss in surgery
38
Succinylcholine
Muscle relaxation for surgery, tracheal intubation, control of ventilation, convulsions
39
Curare
Muscle relaxation for surgery, tracheal intubation, control of ventilation, convulsions
40
Atracurium
Muscle relaxation for surgery, tracheal intubation, control of ventilation, convulsions
41
Cisatracurium
Muscle relaxation for surgery, tracheal intubation, control of ventilation, convulsions
42
Mivacurium
Muscle relaxation for surgery, tracheal intubation, control of ventilation, convulsions
43
Pancuronium
Muscle relaxation for surgery, tracheal intubation, control of ventilation, convulsions
44
Vecuronium
Muscle relaxation for surgery, tracheal intubation, control of ventilation, convulsions
45
Metaraminol
Vasopressor (hypotension – not shock)
46
Methoxamine
hypertension?
47
Phenylephrine
Nasal decongestant, vasopressor, mydriatic, overcome hypotension, local vasoconstrictor
48
- a-methyldopa
Can be used for hypertension
49
- Clonidine
Can be used for hypertension
50
- Guanabenz
Can be used for hypertension
51
Amphetamine
Vasopressor
52
Ephedrine
Vasopressor, mydriatic, nasal decongestant, CNS stimulant, chronic orthostatic hypotension, stress incontinence
53
Dipivefrin
Open angle glaucoma
54
Epinephrine
Anaphylactic shock, severe allergic reactions, open glaucoma, slow profuse bleeding, increase systolic BP (B1/A1 effects), heart block/cardiac arrest
55
Norepinephrine
Vasopressor (shock) (IV only)
56
Dobutamine
Congestive heart failure, cardiogenic shock following MI
57
Isoproterenol
AV block, asthma – increase in cardiac output and decreased MAP with vasodilation
58
Albuterol
Bronchial asthma
59
Metaproterenol
Vasopressor (hypotension – not shock), bronchial asthma
60
Terbutaline
Asthma, relax pregnant uterus
61
Bromocriptine
Anti-parkinson agent with CNS effects
62
Dopamine
Vasopressor, very effective for shock, cardiogenic shock following MI
63
Doxazosin
Urinary obstruction
64
Prazosin
Hypertension – oral – 12 hours – urinary obstruction
65
- Tamsulosin
Urinary obstruction
66
- Terazosin
Urinary obstruction
67
Phenoxy-benzamine
Lasts about 24 hours – oral or IV – pheochromocytoma (management of hypertension post-op)
68
Phentolamine
Pheochromocytoma – preoperative management of hypertension/ inoperative or metastatic tumors
69
Labetalol
Anti-hypertensive
70
Atenolol
Effective anti-hypertensive w/o constriction of bronchial smooth muscle (asthma)
71
Betaxolol
Effective anti-hypertensive w/o constriction of bronchial smooth muscle (asthma), open glaucoma
72
Metoprolol
Effective anti-hypertensive w/o constriction of bronchial smooth muscle (asthma)
73
Nadolol
Antihypertensive
74
- Carteolol
Open angle glaucoma
75
- Levobunolol
Open angle glaucoma
76
- Metipranolol
Open angle glaucoma
77
Pindolol
Antihypertensive
78
Propranolol
Antihypertensive, anti-arrhythmic, angina pectoris, migraines, prophylactics to prevent MI
79
Timolol
Prophylactics to prevent MI, antihypertensive, angina pectoris, decrease IOP (glaucoma)
80
a-methyldopa
Antihypertensive agent
81
Guanethidine
Orally effective hypertensive agent
82
Reserpine
Very potent, orally effective, long duration
83
- Cocaine
Hemostasis during surgery
84
- DMI (desmethyl-imipramine)
Hemostasis during surgery
85
Tyramine
Vasopressor (shock or hypotension)
86
Pseudoephedrine
Nasal congestion
87
- Acetazolamide
Decrease aqueous humor production – open angle glaucoma
88
-Dichlorphenamide
Decrease aqueous humor production – open angle glaucoma
89
- Dorzolamide
Decrease aqueous humor production – open angle glaucoma
90
Botulinum Toxin A
Blepharospasm (eyelid problem) and squinting (extraocular muscles)
91
Azathioprine
Renal and other tissue transplantation, auto-immune disease
92
Cyclophosphamide
Auto-immune diseases and bone marrow transplant
93
Leflunomide
Rheumatoid arthritis (drug of choice), some auto-immune
94
Methotrexate
Rheumatoid arthritis (drug of choice), some auto-immune
95
Mycophenolate mofetil
Solid organ transplant, some auto-immune disease
96
Prednisone
First-line for solid organ and hematopoietic stem cell transplant, management of various immune-disorders
97
Sirolimus
Preserve solid organ transplants, steroid-resistant graft-versus-host disease in hematopoietic stem cell transplants
98
Cyclosporine
Kidney, liver, and cardiac transplants – autoimmune disorders and inflammatory diseases (often combined with another drug)
99
Tacrolimus (FK506)
Kidney, liver, and cardiac transplants – autoimmune disorders and inflammatory diseases (often combined with another drug)
100
Anti-T cell globulin
Prolonged T cell depletion (more than 1 year) – late rejection as lymphoid system recovers
101
Alemtuzumab
Produces prolonged depletion of T cell and other cells of immune system (1 year)
102
Basiliximab
Depletes only antigen-activated T cells so reduced incidence of infection and malignancy
103
Rh (D) immune globulin
Rh hemolytic disease
104
Belatacept
Kidney transplantation to prevent rejection
105
Interleukin-2
Metastatic melanoma and renal cell carcinoma
106
IFN-y
Increase inflammatory response
107
BCG
Cancer therapies
108
Cetirizine
Allergic rhinitis
109
Cyclizine
Motion sickness
110
Dimenhydrinate
Allergic rhinitis, motion sickness
111
Diphenhydramine
Motion sickness, allergic rhinitis
112
Fexofenadine
Allergic rhinitis
113
Loratadine
Allergic rhinitis
114
Promethazine
Motion sickness
115
Adalimumab
Parenteral only – rheumatoid arthritis and Crohn’s disease
116
Etanercept
Parenteral only – rheumatoid arthritis and Crohn’s disease
117
Infliximab
Parenteral only – rheumatoid arthritis and Crohn’s disease
118
Anakinra
Rheumatoid arthritis (short ½ life, daily injection)
119
Tofacitnib
Rheumatoid arthritis (oral – 5mg bid)
120
Aspirin
OTC analgesic, antipyretic, cardiovascular prophylaxis, anti-inflammatory
121
Diclofenac
Rx arthritis/anti-inflammatory
122
Diclofenac w/ misoprostol
Rx arthritis/anti-inflammatory
123
Ibuprofen
OTC analgesic, antipyretic, anti-inflammatory
124
Indomethacin
Rx arthritis/anti-inflammatory
125
Ketorolac
Post-surgical analgesic
126
Naproxen
OTC analgesic, antipyretic, Rx anti-inflammatory
127
Acetaminophen
Analgesic and antipyretic effects (not anti-inflamm)
128
Celecoxib
Anti-inflammatory, antipyretic, analgesic – osteoarthritis and rheumatoid
129
Rofecoxib
Anti-inflammatory, antipyretic, analgesic – osteoarthritis and rheumatoid
130
Albuterol
Inhaled form – short term relief of asthma
131
Salmeterol w/ fluticasone
Inhaled form but longer acting relief of asthma
132
-Beclomethasone
Aerosol inhalation for asthma
133
- Budesonide
Aerosol inhalation for asthma
134
- Fluticasone
Aerosol inhalation for asthma
135
- Triamclinolone
Aerosol inhalation for asthma
136
Prednisone
Oral – intermediate term relief, reduction in inflammation and hyper-responsiveness to control asthma
137
- Montelukast
Oral administration – can reduce corticosteroid dosage for asthma
138
- Zafirlukast
Oral administration – can reduce corticosteroid dosage for asthma
139
Zileuton
Oral administration – asthma
140
- Cromolyn
Inhaled aerosol – effective prophylactically for asthma
141
- Nedocromil
Inhaled aerosol – effective prophylactically for asthma
142
Ipratropium
Inhalation – useful for asthma patients intolerant of B2 agonists
143
Theophylline
Long-term maintenance – oral therapy of asthma
