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Neuropsychopharmacology > Drugs > Flashcards

Drugs Flashcards

1
Q

Bromocriptine

A

Full agonist
D2 receptors
Antiparkinsonian

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2
Q

^9-THC

A

CB1 receptor

Full agonist

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3
Q

Morphine

A

Mue opiate receptor

Full agonist

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4
Q

Nicotine

A

Nicotinic AcH receptors
full agonist
Muscle contraction or twitching

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5
Q

Verenicline(chantix)

A

Causes smoking to have less effect acts on a nicotinic AcH receptor
Partial agonist

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6
Q

Haloperidol

A

D2 receptor
Competitive antagonist
Antipsychotic
Gi

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7
Q

Clozapine

A

Dopamine receptors
Competitive antagonist
Atypical antipsychotic

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8
Q

Reserpine

A

blocks DA storage and depletes DA

decreases 3-MT, but increases DOPAC & HVA

(VMAT-1&2)

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9
Q

tropolone

A

COMT inhibitor

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10
Q

phenelzine (Nardil)

A

MAO inhibitors
non-specific
Antidepressents

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11
Q

moclobemide

A

MAO-A

NE is a substrate for MAO-A

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12
Q

deprenyl

A

MAO-B (at low doses, tends to affect DA more; used as an antiparkinsonian drug)

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13
Q

Catacholamine RELEASING AGENTS (Calcium independent)

A

=d-amphetamine (Dexedrine)
=l-amphetamine (Benzedrine)
=methamphetamine (Methedrine, “meth”; “crank”); stimulate release of monoamines, act as major stimulants, used to treat ADHD, common recreational drug

Methylphenidate (Ritalin): stimulates catecholamine release, acts as major stimulant, used to treat ADHD

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14
Q

ropinirole

A

D2 agonist

Gi

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15
Q

Catacholamine UPTAKE INHIBITORS - blocking transporter levels of transmission is high (more transmitter in the synapse)

A 
Amphetamine
 Cocaine 
Methylphenidate (Ritalin) 
GBR 12909 (DA) 
Bupropion (Welbutrin, Zyban) (DA/NE) 
Desipramine (NE) anti depressent
DAT is dopamine transporter 
Sert for seratonin 
Nat norepinephrin
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16
Q

PCPA

A

inhibits TrypH, blocks 5-HT synthesis

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17
Q

Tryptophan

A

Precursor

Deprevation reduces 5-HT

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18
Q

Tetrabenazine

A

(VMAT-2; less effect on 5-HT)
Storage of monoamine depletion and blocking

Block vesicular storage of monoamines (VMAT inhibitors)

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19
Q

p-chloroamphetamine;

A

5-HT RELEASE
potent at release of 5HT
higher doses of other amphetamines also release 5-HT

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20
Q

Mianserin

A

5-HT2 family antagonist

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21
Q

Pimavanserin

A

5-HT2A inverse agonist

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22
Q

clozapine, risperidol

A

Atypical Antipsychotics: clozapine, risperidol and related drugs are antagonists or inverse agonists of 2A and/or 2C receptor subtypes; many hallucinogens (e.g. LSD) also bind to 2A
Seratonin

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23
Q

Fluoxetine (prozac)

A

5_HT uptake

Selective in terms to DA and Epi and Norepi

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24
Q

Cocaine

A

Inhibit CA uptake
Uptake of seratonin
Non selective

25
Q

Amphetamine

A

Higher doses affect uptake of seratonin

26
Q

AcH esterase inhibitors ( blocking enzymatic enzymes) elevating Ach levels aka anticholinesterases

A

Physostigmine
Tacrine (alzaheimrs )
Galantamine (alzheimers)
DFP (organophosphate) irreversable inhibitors. Toxicity in farmers insecticides
Sarin nerve gases irreversable binds covalntly

27
Q

Hemicholinium-3

A

Block choline transporter

Less moves into the neuron and this reduces the synthesis of Ach

28
Q

Scopolamine

A

Muscurinic antagonist

antiparkinsonian,

hallucinogenic (high doses)

Autonomicsystem

produce dry mouth and constipation, and dilate pupils.

Drugs that block muscarinic receptors

29
Q

Atropine

A

Muscurinic Antagonist

antiparkinsonian,

hallucinogenic (high doses)

Drugs that block muscarinic receptors can produce dry mouth and constipation, and dilate pupils.

30
Q

Muscurine

A

Muscurinic agonist

31
Q

Pilocarpine

A

Muscurininc agonist

32
Q

Mecamylamine

A

Nicotinic antagonist

33
Q

Curare

A

Nicotinic antagonist

used for research; can be lethal, stops the action of the diaphragm muscle; was used in blow darts and arrows in South America

34
Q

Olanzopine

A

Block muscurinic receptors

35
Q

MK 801 (dizocilpine)

A

noncompetitive NMDA antagonist, neuroprotective

36
Q

PCP (phencyclidine) and ketamine

A

un-competitive NMDA antagonists.

37
Q

Propranolol (Inderal)

A

b adrenergic competitive antagonists

used to treat high blood pressure

38
Q

strychnine

A

Competitive antagonist in glycin

Rat poisin

39
Q

physostigmine, tacrine, galantamine

A

tacrine & galantamine used to treat Alzheimer’s disease

reversible anticholinesterases

Affect the metabolism of Ach

40
Q

nsecticides such as DFP, and the nerve gas Sarin

A

irreversible anticholinesterases

41
Q

Bitopertin

A

GLYT-1 inhibitor, was evaluated as an adjunct treatment for schizophrenia

42
Q

Rapastinel

A

GLY is a “co-agonist” on the NMDA receptor

is a partial agonist of this site

43
Q

istradefylline and preladenant

A

A2A antagonists such as istradefylline and preladenant have been evaluated in clinical trials as antiparkinsonian drugs; istradefylline is approved for use in Japan, recently approved in US

44
Q

Caffeine and other methylxanthines

A

are non-selective adenosine antagonists.

45
Q

THC, CP55940

A

CB1 Agonists:
CP is much more potent
Thc could be an anelgesic

46
Q

AM4113;

rimonabant

A

CB1 Antagonists/inverse agonists

Rimonabat was studied as a food suppressent

47
Q

Codeine

A

agonists of opiote receptors

48
Q

heroin

A

semi-synthetic drug

49
Q 
Propoxyphene (Darvon) 
Meperidine (Demerol) 
Fentanyl (Sublimaze) mixed with heroin due to high potency and affinity
Knee receptors
Oxycodone (OxyContin)
A 
Synthetic opiates (“opioids”):
Anesthesia and surgery uses
50
Q

Naloxone ( receptor)

A

Opiate receptor antagonist

51
Q

Peptides

A

Oxytocin Vasopressin Cholecystokinin (CCK) Neuropeptide Y

Tachykinins (neurokinins) Substance P Kassinin Neurokinin A Eledoisin

52
Q

methamphetamine

A

It not only blocks DAT, it is a substrate, transported into the terminal
• Once inside the terminal, it stimulates release of DA
• Inside the terminal, it also blocks VMAT-2; it also is a substrate, transported into the vesicles
• It also inhibits MAO

53
Q

FG7142

A

(benzodiazepine site) has effects opposite to benzodiazepines; can be described as a negative allosteric modulator

54
Q

Pimavanserin:

A

5-HT2A inverse agonist;

used to treat hallucinations in Parkinson’s disease patients

55
Q

neostigmine,

A

AChesterase inhibitor, used to treat neuromuscular dysfunction

56
Q

stimulants, cold medicines/diet pills (ephedrine, phenylpropanolamine) that act on NE

A

These drugs can increase heart rate & blood pressure, and produce other signs of sympathetic activation

57
Q

anticholinesterases, muscarinic agonists

A

Drugs that Stimulate ACh transmission: stimulate parasympathetic activity

Can cause SLUD!!! Salivation Lacrimation Urination Defecation YUK!!!!!!!!!!!!!

58
Q

tropicamide,

A

Antagonist of muscurinic

can produce dry mouth and constipation, and dilate pupils.

Drugs that block muscarinic receptors

Dialating pupils for opthamologist

Neuropsychopharmacology (4 decks)

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