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Neuropsychopharmacology > Synthesis And Metbolism > Flashcards

Synthesis And Metbolism Flashcards

1
Q

Catacholamine’s

A

Tyrosine — L-Dopa — Dopamine— norepinephrin—Epinephrin

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2
Q

How does Tyrosin become L-Dopa

A

TH- tyrosin hydroxylaze

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3
Q

L-Dopa to Dopamine

A

LAAD

L-AROMATIC AMINO ACID DECARBOXYLASE DOPAMINE

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4
Q

Dopamine to Norepinephrine

A

DOPAMINE b-HYDROXYLASE

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5
Q

Norepinephrine to Epinephrine

A

PHENYLETHANOLAMINE N-METHYL TRANSFERASE

PNMT

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6
Q

Dopamine metabolites

A

DOPAC (3,4-dihydroxyphenylacetic acid)
HVA (homovanilic acid)
3-MT (3-methoxytyramine)

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7
Q

Dopamine metabolism enzymes

A 
MAO
(monoamine oxidase) 
COMT
(catechol O-methyl transferase) 
ADH
(aldehyde dehydrogenase)
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8
Q

DOPAMINE to DOPAC

A

MAO & ADH

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9
Q

DOPAN to HVA

A

COMT

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10
Q

DOPAMINE to 3-MT

A

Comt

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11
Q

3-MT to HVA

A

MOA & ADH

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12
Q

NOREPINEPHRINE METABOLITES

A

VMA (vanillylmandelic acid)

MHPG (3-Methoxy-4-hydroxyphenylglycol)

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13
Q

NorEpinephrine to VMA

A

MOA & ADH & COMT

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14
Q

NorEpinephrine to MHPG

A

AR = aldehyde reductase

MOA & AR & COMT

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15
Q

Seratonin synthesis

A

TRYPTOPHAN to 5-HYDROXY TRYPTOPHAN (5-HTP) to SEROTONIN (5-HT)

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16
Q

TRYPTOPHAN To 5-HYDROXY TRYPTOPHAN (5-HTP)

A

TRYPTOPHAN HYDROXYLASE

Enzyme

17
Q

5-HYDROXY TRYPTOPHAN (5-HTP) to SEROTONIN (5-HT)

A

L-AROMATIC AMINO ACID DECARBOXYLASE

18
Q

5-HT METABOLITE

A

5-HIAA (5-hydroxyindoleacetic acid)

19
Q

5-HT to 5-HIAA

A

MOA & ADH

20
Q

AcH synthesis

A

Choline and AcytlecoA (acytl group) are precursors that are joined together by CAT (choline acetyltransferase)

21
Q

Metabolism of AcH

A

One enzyme involved acytlcholine esterase

And give choline and acetate

22
Q

Metabolism of AN

A

FAAH

23
Q

Peptides synthesis (opiates)

A

precursor peptides (e.g. proopiomelanocortin (POMC), proenkephalin, prodynorphin)
Longer sequence and then they are clipped off
Long is POMC and has sequence of others

Neuropsychopharmacology (4 decks)

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