Flashcards in Drugs Deck (6)
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1
Isoniazid (INH):
- MOA?
- Cidal/static?
- PK?
- Toxicity? (2)
- Resistance? (2)
- Route?
- Spectrum? IC activity?
- Decreases synthesis of mycolic acid; bacterial catalase peroxidase (katG) needed to convert to active form
- Cidal for active; static for latent
- Different acetylator speed makes a difference on levels/dose
- Hepatotoxicity, Neurotoxicity (B6 Pyrodoxine)
- Rapidly via inhA/katG mutations
- Oral
- Mycobacteria only; Good
2
Rifampin:
- MOA?
- Selective toxicity?
- Route?
- Spectrum?
- IC activity?
- Resistance? Effect what?
- Toxicity? (3)
- Cidal inhibition of RNA polymerase initiation
- Bacteria have different RNA polymerase
- Oral
- Myco + gram (+)
- good
- RNA poly (rpoB); mitochondria
- Minor hepato; red/orange fluids; (rifabutin in HIV because it doesn't effect p450)
3
Ethambutol:
- MOA?
- Selective toxicity?
- Route?
- Spectrum?
- IC activity?
- Good aspect? Bad?
- Resistance?
- Toxicity? (2)
- TB static; other myco-cidal; inihibits arabinosyl transferase
- arabinosyl transferase
- Oral
- Myco only
- Modest
- Good lung distribution; doesn't penetrate macs but can hit mitochondria
- emb genes
- optic neuropathy (red-green color blind); gout
4
Pyrazinamide:
- MOA?
- Selective toxicity?
- Route?
- Spectrum?
- IC activity?
- Resistance?
- Toxicity (2)
- Pregnancy?
- Cidal unknown MOA
- Not known
- Oral
- Myco only
- Variable
- pncA gene
- Gout, hepatotoxicity
- NOT IN PREGNANCY!!!
5
Streptomycin:
- MOA?
- Selective toxicity?
- Route?
- Spectrum?
- IC activity?
- Cidal inhibition of protein synthesis
- Aminoglycoside
- IV
- Myco + gram (-)
- Poor
6
