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Flashcards in Drugs Deck (29)
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1
Q

Mesna

A

Reacts in the bladder with acroleine, a metabolite of the anticancer drug, cyclophosphamide, thus preventing hemorrhaguc cystitis

2
Q

Mannitol

A

increases the osmolarity of various body fluids. This effect can promote diuresis or reduction of cerebral edema.

3
Q

cholestyramine, colestipol and colesevelam

A

Bind bile acids in the intestinal lumen and prevent their, reabsorption. Used to treat hyperlipidemia.

4
Q

Dimercaprol

A

chelates heavy metals

5
Q

Structural analogs of pyrimidines and purines

A

can incorporate into nucleic acids and alter their functions. Used for cancer and antiviral chemotherapy.

6
Q

Phenoxybenzamine

A

Irreversible alpha-adrenoceptor blocker used in the txt of pheochromocytoma

7
Q

Aspirin & omeprazole

A

irreversible enzyme inhibitors

8
Q

Ketamine

A

Non-competitive antagonist

  • It is an IV anesthetic
  • It is a noncompetitive antagonist at NMDA receptors
9
Q

Protamine vs Heparin

A

chemical antagonist

10
Q

Epinephrine vs histamine

A

physiological antagonists

11
Q

Famotidine and metoprolol

A

Inverse agonists

- shift receptors to an inactive state.

12
Q

Imatinib (Gleevec)

A

Tyrosine Kinase inhibitor

13
Q

Cholinergic agonists: Direct acting drugs

A
Acetylcholine
Bethanechol
Carbachol
Methacholine
Muscarine
Arecoline
Pilocarpine
Nicotine
14
Q

Cholinergic agonists: AchE Inhibitors

A
Edrophonium
Physostigmine
Neostigmine
Pyridostigmine
Echothiophate
Malathion
Parathion
Tabun
Sarin
Soman
Donepezil
Rivastigmine
Galantamine
15
Q

Cholinergic agonists: Reactivator of AChE

A

Pralidoxime

16
Q

Cholinergic antagonists: Muscarinic Antagonists

A
Atropine
Scopolamine
Ipratropium
Tiotropium
Homatopine
Cyclopentolate
Tropicaminde
Benztropine
Trihexyphenidyl
Glycopyrolate
Tolterodine
17
Q

cholinergic antagonist: Ganglion Blockers

A

Mecamylamine
Trimethaphan
Hexamethonium
- were used for HTN

18
Q

Cholinergic antagonist: Neuromuscular blockers

A

Tubocurarine

Succinylcholine

19
Q

Cholinergic antagonist: Drugs that act presynaptically

A

Hemicholinium
Vesamicol
Botulinum Toxin

20
Q

Adrenergic agonists: Direct acting agonists

A

Endogenous catecholamines:
epinephirne
Norepinephrine
Dopamine

21
Q

diphenhydramine

A

Antihistamine. H1 receptor antangonist used to treat allergic reactions.
- crosses BBB to antagonize R’s in CNS, leading to somnolence.

22
Q

Off Target effects

A

Terfenadine (an antihistamine), also inhibits a cardiac potassium channel (hERG). Drug has been withdrawn.

Enantiomers of drugs
-R and S thalidomide to treat morning sickness. R safe, S potent teratogen

Unintended activation of different recepors subtypes

Many receptors have many different subtypes (eg, P2Y recpetors > 8 KNown)

23
Q

Production of toxic metabolite

A

A drug metabolite can have an adverse effect. (eg. excess acteminophen & NAPQI)

24
Q

Quaternary ammmonium Muscarininc antagonists

A

Ipratropium and Tiotropium
- used as inhalation drugs in the txt of COPD
- and adjuvant for asthma therapy
- Bronchodilation [M3]
Glycopyrrolate:
- used orally to inibit GI motility
- Parenterally used to prevent bradycardia during surgical procedures

25
Q

Tertiary amines that indicated in parkinsonism

A

Benztropine & Trihexyphenidyl

- Restores balance of input after loss of dopamineric neurons in the nigrostriatal pathway

26
Q

Tertiary amines that cause Mydriasis and cycloplegia

A

Homatropine, cyclopentolate, Tropicamide

- Mydriasis and cycloplegia: preferred over atropine because of shorter duration of action

27
Q

Tertiary amine that relaxes smooth muscle and is used for txt of overactive bladder

A

Tolterodine

28
Q

what is the txt for Malignant hyperthermia caused by succinylcholine a cholinergic antagonist (neuromuscular blocker)?

A

Dantrolene

29
Q

cholinergic antagonists drug that acts presynaptically to block choline transporter [CHT1] thus preventing uptake and synthesis of acetylcholine

A

Hemicholinium