Drugs Flashcards
(28 cards)
pharmacokinetics
bodies action on the drug
pharmacodynamic
drugs action on the body
what kind of environment do acidic drugs need for absoption
acidic
what kind of environment do basic drugs need for absoption
basic
name acidic drugs
phenytoin
aspirin
penicillin
name basic drugs
diazepam
morphine
what binds to basic drugs
alpha 1 acid glycoprotein
what binds to acidic drugs
albumin
elderly have low albumin but high A1 AG
what drugs are increased in volume distribution in elderly
lipophilic drugs eg diazepam
why is there a lower volume distribution of hydrophilic drugs in elderly
decreased body water
eg lithium
what is reduced in terms of metabolism of drugs in elderly
decreased first pass metabolism
reduced liver function
what is different in elderly in terms of excretion
lower gfr
what drugs may need increased doses in elderly
beta blockers
how should dosing be done in elderly in general
in general need lower doses
examples of drugs with narrow therapeutic window
warfarin lithium digoxin gentamicin vancomycin
common side effect of amlodipine
oedema
grapefruit juice
statin
metronidazole
alcohole
cranberry juice
warfarin
antibiotics which interacts badly with statin
clarithromycin
hyperkalaemia
ACE
spironolactone
deficiency that causes wernickes
B1 thiamine
urinary retention in PDH
decongestants or anticholinergics
lower seizure threshold
antipsychotics
