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FTM > Drugs > Flashcards

Drugs Flashcards

1
Q

diptheria toxin

A

Compound affecting protein synthesis.

Inactivation of ER-2 (elongation factor) by ADP-ribosylation, needed for translocation.

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2
Q

Streptomycin (aminglycoside)

A

Antibiotic inhibition of initiation.

Prevents assembly of ribosome. Binds to 30s subunit.

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3
Q

Tetracycline

A

Antibiotic inhibition of initiation.

Block elongation by preventing aminoacyl-tRNA access to A-site.

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4
Q

Erythromycin (macrolide)

A

Antibiotic inhibition of initiation.
Binds to 50s subunit of the complete 70s ribosome.
Blocks ribosome translocation.

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5
Q

Chloramphenicol

A

Antibiotic inhibition of initiation.
Inhibits peptidyl transferase activity in PROKARYOTES.
At high levels may inhibit mitochondrial translation.
(Eukaryotes=cycloheximide)

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6
Q

Cycloheximide

A

Antibiotic inhibition of initiation.
Inhibits EUKARYOTIC peptidyl transferase activity.
(Prokaryotes=chloramphenicol)

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7
Q

Puromycin

A

Antibiotic inhibition of initiation.

Causes premature termination of translation in both prokaryotes and eukaryotes.

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FTM (6 decks)

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