drugs Flashcards
(8 cards)
1
Q
What are the proton pump inhibitors?
A
Omeprazole Lansoprazole Esomeprazole Pantoprazole Dexlansoprazole
2
Q
What is the MOA of PPI’s?
A
Irreversibly inhibits H+/K+ ATPase in parietal cells
3
Q
What are PPI’s used to treat?
A
Peptic ulcer disease Esophageal reflux Zollinger-Ellison syndrome Gastritis Stress/ICU prophylaxis H pylori
4
Q
What are some adverse affects of PPI’s?
A
Increase risk of C diff and pneumonia Long term use can lead to decrease in Mg serum Tolerance to histamine Rebound hyper-secretion of acid Decrease in b12, Iron, Ca and zinc ECL hyperplasia Decrease affectivness of lysosomes Block p-Glycoproteins
5
Q
Why is blocking of P-glycoprotein significant in PPI’s?
A
- Can lead to drug toxicity because they are not being excreted by the protein
- use to efflux drugs and other substances out of the brain (sit in the BBB)
6
Q
What are the Antacids?
A
Aluminum hydroxide
Magnesium hydroxide
Calcium carbonate
Sodium Bicarbonate
7
Q
What is the MOA of antacids?
A
Weak bases
- alters gastric and urinary pH and delays gastric emptying
- Think what other affects this has (pharmacokinetics, absorption and urinary excretion
- all cause hypokalemia
8
Q
What is important about PPI’s in terms of absorption?
A
Acid labile
need acidic environment
Take 18 hours to make new H+/K+ pumps
Short 1/2
