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Flashcards in drugs Deck (8)
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1

What are the proton pump inhibitors?

Omeprazole
Lansoprazole
Esomeprazole
Pantoprazole
Dexlansoprazole

2

What is the MOA of PPI's?

Irreversibly inhibits H+/K+ ATPase in parietal cells

3

What are PPI's used to treat?

Peptic ulcer disease
Esophageal reflux
Zollinger-Ellison syndrome
Gastritis
Stress/ICU prophylaxis
H pylori

4

What are some adverse affects of PPI's?

Increase risk of C diff and pneumonia
Long term use can lead to decrease in Mg serum
Tolerance to histamine
Rebound hyper-secretion of acid
Decrease in b12, Iron, Ca and zinc
ECL hyperplasia
Decrease affectivness of lysosomes
Block p-Glycoproteins

5

Why is blocking of P-glycoprotein significant in PPI's?

-Can lead to drug toxicity because they are not being excreted by the protein
- use to efflux drugs and other substances out of the brain (sit in the BBB)

6

What are the Antacids?

Aluminum hydroxide
Magnesium hydroxide
Calcium carbonate
Sodium Bicarbonate

7

What is the MOA of antacids?

Weak bases
- alters gastric and urinary pH and delays gastric emptying
- Think what other affects this has (pharmacokinetics, absorption and urinary excretion
- all cause hypokalemia

8

What is important about PPI's in terms of absorption?

Acid labile
need acidic environment
Take 18 hours to make new H+/K+ pumps
Short 1/2