Flashcards in drugs Deck (8)
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1
What are the proton pump inhibitors?
Omeprazole
Lansoprazole
Esomeprazole
Pantoprazole
Dexlansoprazole
2
What is the MOA of PPI's?
Irreversibly inhibits H+/K+ ATPase in parietal cells
3
What are PPI's used to treat?
Peptic ulcer disease
Esophageal reflux
Zollinger-Ellison syndrome
Gastritis
Stress/ICU prophylaxis
H pylori
4
What are some adverse affects of PPI's?
Increase risk of C diff and pneumonia
Long term use can lead to decrease in Mg serum
Tolerance to histamine
Rebound hyper-secretion of acid
Decrease in b12, Iron, Ca and zinc
ECL hyperplasia
Decrease affectivness of lysosomes
Block p-Glycoproteins
5
Why is blocking of P-glycoprotein significant in PPI's?
-Can lead to drug toxicity because they are not being excreted by the protein
- use to efflux drugs and other substances out of the brain (sit in the BBB)
6
What are the Antacids?
Aluminum hydroxide
Magnesium hydroxide
Calcium carbonate
Sodium Bicarbonate
7
What is the MOA of antacids?
Weak bases
- alters gastric and urinary pH and delays gastric emptying
- Think what other affects this has (pharmacokinetics, absorption and urinary excretion
- all cause hypokalemia
8
