DRUGS

Question 1

What is propanolol?

Answer 1

Generalised beta-antagonist; best we have for beta2s but not clinically useful

Question 2

What is salbutamol?

Answer 2

A beta2 agonist. it is specific and usually used to treat asthma

Question 3

What is clonidine?

Answer 3

An alpha2 agonist. Used to inhibit SNS transmission e.g sedation.

Question 4

What is yohimbine?

Answer 4

An alpha2 antagonist. Used to reverse effects of clonidine

Question 5

What is isoprenaline?

Answer 5

A general beta-adrenoceptor agonist. Not good for asthma as increases HR too much

Question 6

What is atenolol?

Answer 6

A specific beta1 antagonist - slows HR - used for hypertension

Question 7

What is dobutamine?

Answer 7

A specific beta1 agonist - increases HR - use in heart failure

Question 8

What is phenylephrine?

Answer 8

A specific alpha1 agonist - used as a decongestant

Question 9

What is phentolamine?

Answer 9

A non-specific alpha-adrenoceptor antagonist

Question 10

What is prazosin?

Answer 10

A specific alpha-1 antagonist - useful in hypertension though risk of large fluctuations in blood pressure when change posture, causing dizziness and fainting

Question 11

What are two drugs that inhibit NA uptake by presynaptic neuron?

Answer 11

Cocaine, desipramine

Question 12

What is an example of a MAO blocker?

Answer 12

Moclobemide

Question 13

What is are two examples of indirectly acting sympathomimetics?

Answer 13

Amphetamine, ephedrine

Question 14

What are two muscarinic AChR antagonists?

Answer 14

Atropine, hyoscine, ipratopium

Question 15

What are three muscarinic AChR agonists?

Answer 15

pilocarpine, carbachol, bethanecol

Question 16

What are two therapeutic anticholinesterases?

Answer 16

Physostigmine

Neostigmine

Question 17

What are some nAChR antagonists?

Answer 17

NMJ
- vecuronium, d tubocurare (non-depolarising)
- suxamethonium (depolarising)
Ganglion - hexamethonium

Question 18

nAChR agonist?

Answer 18

Nicotine

Question 19

What does icatibant do?

Answer 19

Antagonist at bradykinin R

Question 20

What do NSAIDs do? example?

Answer 20

Aspirin

• inhibit COX
• reduce PG synthesis > PG and BK dont surmount

Question 21

What do glucocorticoids do? Example?

Answer 21

Dexamethosone

• Inhibit PLA2
• Inhibit COX
• inhibit cytokine formation
• inhibit adhesion molecule expression

Question 22

Which drug is an example of a generalised alpha adrenoceptor antagonist?

Answer 22

Phentolamine

Question 23

Which drug is an example of a generalised beta adrenoceptor antagonist?

Answer 23

Propanolol

Question 24

Which drug is an example of a generalised beta adrenoceptor agonst?

Answer 24

Isoprenaline

Question 25

Which drug is an example of a specific alpha1 agonist?

Answer 25

Phenylephrine - decongestant

Question 26

Which drug is an example of a specific alpha1 antagonist?

Answer 26

Prazosin - hypertension

Question 27

Which drug is an example of a specific beta1 agonist?

Answer 27

Dobutamine - heart failure

Question 28

Which drug is an example of a specific beta1 antagonist?

Answer 28

Atenolol - hypertension

Question 29

Which drug is an example of a specific beta2 agonist?

Answer 29

Salbutamol

Question 30

Which drug is the best we have for beta2 antagonist?

Answer 30

Propanolol

Question 31

Which is drug is a generalised agonist for beta adrenoceptors?

Answer 31

Isoprenaline

Question 32

Which drug would you give for prolonging NA effects - slow onset?

Answer 32

Moclobamide

Question 33

Which drug would you give for prolonging NA effects - fast onset?

Answer 33

Desipramine

Question 34

What is amphetamine?

Answer 34

An indirectly acting sympathomimetic

Question 35

What is carbachol?

Answer 35

A mAChR agonist

Question 36

What is pilocarpine?

Answer 36

A mAChR agonist