Drugs

Question 1

4 drug types which inhibit parietal cells secretion

Answer 1

parietal - acid 
PPIs (omeprazole) 
Muscarinic receptor antagonists 
H2 receptor antagonists
NSAIDS

Question 2

t/f warfarin can cause peptic ulcers

Answer 2

false

NSAIDS - drugs

Question 3

when treating peptic ulcers, what 3 things will need to be considered

Answer 3

h.pylori? if so eradicate
incr mucosal strength
reduce HCL

Question 4

name 2 mucosal strengtheners

Answer 4

ssucralfate

bismuth chealate

Question 5

ranitidine

Answer 5

H2 receptor antagonist

reduces ACh and gastric acid secretion

Question 6

4 types of antiemetic drugs

Answer 6

dopamine antagonists
5HT3 receptor antagonists
H1 receptor antagonists
Antimuscarinic

Question 7

haloperidol 
prochlorperazine 
droperidol 
Chlorpromazine 
these are all

Answer 7

Dopamine antagonists

Question 8

how does dopamine antagonists work, when would they be used

Answer 8

block chemoreceptor trigger zone (CTZ)

radiation/drug-induced sickness

Question 9

which types of drugs end in ‘setron’

Answer 9

5ht3 antagonists

Question 10

commmon side effect of Ondansetron

Answer 10

headache

Question 11

other than ondansetron, give an example of a 5ht3 receptor antagonists

Answer 11

Gransetron

Question 12

how does H1 receptor antagonists work

Answer 12

blocks H1 in vestibulei nuclei and NTSA

Question 13

give an example of h1 antagonist and when it would be used

Answer 13

promethazine
(also cyclizine, cinnarizine)
most sickness, post op sickness

Question 14

which h1 antagonist - promethazine, cyclizine, cinnarizine, is linked to menieres disease

Answer 14

cinnarizine

Question 15

dicyclomine is what type of drug, when would it be used 2

Answer 15

antimuscarinic
motion sickness
IBS

Question 16

antimuscarinic drugs (scopolamine, dicyclomine) have many adverse affects due to their interaction with the Para ANS/ what are they 4

Answer 16

blurred vision
urinary retention
xerostomia
sedation

Question 17

triple threat therapy is used in chemo-induced emesis, what is this

Answer 17

5HT3 antagonist
Dexamethasone
Aprepitant

Question 18

when would hyperemesis gravidarma occur

Answer 18

during pregnancy - intractable emesis ]

Question 19

what is the 1st and 2nd line treatment for hyperemesis gravidarma

Answer 19

1st - H1 Antagonists (promethazine, cyclizine)

2nd - Dopamine ant. (prochloperazine, metoclopramide)

Question 20

explain prokinetic drugs affect on GI and CNS

Answer 20

GI
- incr peristalsis, incr lower ooesophageal sphincter tone

CNS
blocks D2

Question 21

give 2 examples of prokinetic drugs

Answer 21

domperidome

metoclopramide

Question 22

4 types of laxatives

Answer 22

purgatives
softeners
bulk
osmotic

Question 23

methylcellulose

Answer 23

bulk laxative, slow working, improves stool consistency

Question 24

mg sulphate is what type of laxative

Answer 24

osmotic

incr peristalsis, rapid effect

Question 25

docusate sodium is what type of laxative

Answer 25

softener

Question 26

t/f mesalazine is a purgative

Answer 26

false | it is aminosalicylate

Question 27

purgatives work by incr h20 and electrolyte, and peristalsis, give an example and a likely side effect

Answer 27

bisacodyl | ab cramp

Question 28

``` mesalazine sulfalazine olsalazine balsalazide these are .... and used for ```

Answer 28

aminosalicylates IBD flares better in UC

Question 29

IBS is treated using 3 types of drugs, what are they,

Answer 29

Anti-motility Anti-spasmodic Anti-depressent

Question 30

Hyosine is an anti-motility agent t/f

Answer 30

false | anti-spasmodic

Question 31

mebeverine

Answer 31

anti-spasmodic

Question 32

give 3 anti-motility agents

Answer 32

codeine diphinoxylate loperamide

Question 33

amitriptyline is

Answer 33

anti-depressant

Question 34

when are bile acid sequestrants used 2

Answer 34

(prevent bile re-absorption) hyperlipidemia jaundice

Question 35

3 examples of bile acid sequestrants

Answer 35

colesevelam colestipol colestyramine