wk 6 2 Effects of alcohol on liver Flashcards Preview

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Flashcards in wk 6 2 Effects of alcohol on liver Deck (22)
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1
Q

units for men and women? estimates

A

14
pint =2.3
medium wine = 2.3

2
Q

number of admissions per year due to alcohol

A

1 in 20

3
Q

acute effects of alcohol on CNS, GI and Resp

A
CNS
Accidents
Violence
Gastrointestinal
Oesophagitis, Gastritis/ulceration
Acute Pancreatitis
Respiratory
Overdose
Aspiration
4
Q

what are the chronic cardio effets of alcohol

A

hypertension
cardiomyopathy
MI
stroke

5
Q

likely CNS chronic effects

A

neuropathy
cerebeller degeneration
dementia
wernicke-korsakoff’s syndrome

6
Q

underage drinking effects on brain

A

smaller hippocampal memory areas

7
Q

t/f alcohol can cause anaemia

A

true

suppress bone marrow too

8
Q

define foetal alcohol syndrome

A

growth defiency, mental retardation/ intellectual impairment, attention learning disabilityies and behavioural problems due to drinking with foetus in uteroo

9
Q

end product in alcohol metabolism

A

acetate

10
Q

what product is the toxic effect on body due to alcohol metabolism

A

acetaldehyde

11
Q

3 things which acetaldehyde causes

A

inflammation
hepatocyte damahe
stellate cell activation leading to fibrosis

12
Q

which immune cell is required fro inflammation to occur in the kupffer cells

A

TNF-alpha

13
Q

steatosis

A

fatty liver

14
Q

steatosis can lead to

A
alcoholic hepatitis (may be reversed if alcohol stopped) 
cirrhosis
15
Q

outline the spectrum of clinical features of ALD, as the liver starts as steatosis and then cirrhotic

A
malaise
nausea
hepatomegaly
fever
jaundice
sepsis
encephalopathy
ascites 
renal failure 
death
16
Q

signs of chronic liver disease

A
spider nevi 
fetor 
encephalopathy
prolonged prothrombin time 
hypoalbuminaemia
17
Q

signs of portal hypertension

A

caput medusa
hypersplenism
thromobcytopenia

18
Q

how is cirrhosis graded

A

Childs-Turcotte-Pugh score

19
Q

childs score is up to 15, what would get 2 points be

A
ascites - slight
hepatic encephalopathy - grade 1/2
bilirubin  34.2-51.3
albumin 28-35
prothrombin time 4-6
20
Q

alcoholic hepatitis appears as

A
recent excess alcohol 
bilirubin >80
exclusion of other liver diseases
AST <500
hepatomegaly +/- fever+/- leucocytosis +/- hepatic bruit
21
Q

glasgow score greater than 9 on day 1, percentage of 28 day survival

A

46

22
Q

treatment for end stage liver disease and alcoholic hepatitis

A

abstinence

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