Drugs

Question 1

alpha methyldopa

Answer 1

inhibits laad to prevent dopa–> dopamine

Question 2

carbidopa

Answer 2

inhibits laad in periphery to prevent dopa –> dopamine in tx of parkinson’s

Question 3

bromocriptine

Answer 3

d2 agonist for parkinson’s

Question 4

disulfuram

Answer 4

inhibits dopamine beta hydroxylase to prevent dopamine –> NE

Question 5

reserpine

Answer 5

blocks catecholamine reuptake into vesicles via VMAT

Question 6

bretylium

Answer 6

NE release inhibitor –> Vfib

Question 7

guanethidine

Answer 7

NE release inhibitor –> degradation of nerve endings ->htn

Question 8

selegiline

Answer 8

MAOBI –> parkinson’s

Question 9

phenelzine

Answer 9

MAOA/B–> hepatotoxic

Question 10

clorgyline

Answer 10

MAOAI

Question 11

Deprenyl

Answer 11

MAOBI

Question 12

cocaine

Answer 12

NE reuptake inhibitor

Question 13

imipramine

Answer 13

TCA

Question 14

dopamine

Answer 14

inotropic tx of shock

Question 15

dobutamine

Answer 15

inotropic tx of chf

Question 16

amphetamines

Answer 16

increases DA and NE release and blocks reuptake, alpha methyl group to resist MAO degradation

Question 17

fenfluramine

Answer 17

SERT inhibitor and VMAT inhibitor and serotonin releasing agent

Question 18

SSRI

Answer 18

SERT inhibitor for depression and anxiety: fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram; few side effects except serotonin syndrome

Question 19

MDMA

Answer 19

reverses SERT to increase synaptic serotonin –> releaser

Question 20

busiprone

Answer 20

serotonin1a partial agonist for anxiety

Question 21

sumaptriptan

Answer 21

migraines via 5ht1d/f

Question 22

MAOI

Answer 22

tx of depression, causes serotonin syndrome

Question 23

methylphenidate

Answer 23

ritalin, blocks reuptake of DA and NE in ADHD

Question 24

atomoxetine

Answer 24

NE reuptake blocker and increases DA // non stimulant (for those with stimulant side effects)

Question 25

anxiety disorder tx

Answer 25

cbt w/extinction training, benzos (specific and social phobia), ssri's, snri's, atypicals, tca's, maois

Question 26

potent D2 receptor antagonists

Answer 26

first gen haloperidol and 2nd gen risperidone, lurasidone, and aripiprazole

Question 27

weak D2 receptor antagonists

Answer 27

clozapine

Question 28

2nd generation antipsychotics receptors affected

Answer 28

D2 and 5HT2a

Question 29

SNRIs

Answer 29

venlafaxine, duloxetine, etc. blocks both serotonin and ne; side effects include serotonin symptoms + htn, tachycardai

Question 30

bupropion

Answer 30

NDRI (used for nicotine), cause insomnia, anxiety, agitation, anorexia, headache