Drugs acting at the ANS - Cholinergic Receptors Flashcards Preview

MED 1022 > Drugs acting at the ANS - Cholinergic Receptors > Flashcards

Flashcards in Drugs acting at the ANS - Cholinergic Receptors Deck (47):
0

Which is longer presynaptically?

Parasympathetic nerve.

1

Drugs acting on cholinergic synapses can act on.

Ganglia,
Muscarinic receptors,
Neuromuscular junction,
Enhance cholinergic transmission.

2

Action of nicotine.

Dependant on dose.

3

Low dose nicotine.

Stimulation of sensory receptors.

4

High dose.

Depolarisation blockade.

5

Sympathomimetic effects of nicotine.

CVS effects, BP, heart rate and blood pressure.

6

Parasympathomimetic effects of Nicotine.

GIT movement, HCl in stomach.

7

Central effects of nicotine.

Nausea, arousal, high.

8

Where can you find nicotinic neural receptors?

Ganglia, adrenal medulla, sensory nerve endings.

9

Agonists of nicotinic neural.

Ach and nicotine.

10

Antagonists of nicotinic neural.

Hexamethonian, trimethaphan.

11

Nicotinic muscle receptor agoinsts.

Suxamethonium, decamethonium.

12

Nicotinic muscle receptor antagonists?

Tubocurarine, atracurium, mivacurium, vecuronium. (Transmission block). MUSCLE relaxants!

13

Miscarinic agonists can be described as being...

Parasympathomimetics.

14

Type of muscarinic agonists at the heart.

M2.

15

Pilocarpine.

A partial Muscarinic agonist, used to treat Glaucoma. Contract iris smooth muscle. Weak effects in GIT and heart.

16

Bethanocol.

Bladder and bowel stimulation.

17

Agonist at Muscarinic receptors for smooth muscle.

Cause GIT and bronchoconstriction.

18

Muscarinic Antagonists.

Parasympatholytics.

19

Muscarinic antagonists examples.

Atropine and derivatives. Iprtropium, Hycosine, Dcyclomine.

20

Atropine poisoning.

Eye dilation, photphpobia, inhibition of micturition, Tachycardia, CNS - restlessness, delirium, coma, convulsions.

21

Antidote for atropine poisoning.

Anticholinesterase - neostigmine, physostigmine.

22

Uses of atropine.

Adjunct for anesthesia,
Antidote for anticholinesterase poisoning,
Bradycardia,
Antispasmodic.
Reduction of diarhhea (lomotil),
Parkinsons (benztropine).

23

Significant about atropine.

Non selective inhibitor of muscarinic receptors.

24

Main indiactions of atropine.

Bradycardia and anticholinesterase poisoning.

25

Hycosine indication.

Gut spasms

26

Ipratropium indication.

Bronchoconstriction.

27

Benztropine indication.

Parkinsons disease.

28

Types of receptors found in cholinergic nerves?

Muscarinic and Nicotinic.

29

What are the two types of drugs that work at the Neuromuscular junction?

Non depolarising and depolarising.
Inhibitors of acetylcholine synthesis or release.

30

What drugs can cause Nicotinic receptor stimulation?

Nicotine, DMPP, epibatidine, Suxamethonium, decamethonium.

31

If you stimulate muscarinic receptors do you get pumped up or do you relax?

You relax.

32

M3 actions.

Miosis, Salivation, Bonchoconstriction, GIT motilty, Bladder wall contraction.

33

A selective M2 agonist can be used for?

Dysrhytmias.

34

Tropicamide indication.

Dilation of pupil.

35

Muscarine receptor agonists.

ACh, Muscarine, pilocarpine, carbachol and bethanechol.

36

Muscarine antagonists.

Atropine and derivatives.

37

Name drugs that prevent ACh synthesis.

Vesamicol,
Hemicholium.

38

Drugs that inhibit ACh release?

Botulinum and bungaratoxin.

39

How would I cure botulinum poisoning?

Anti toxin, enema.

40

Drugs which are Non depolarising blockers at the NMJ?

Cura's.

41

Depolarising blockers at NMJ.

Suxamethonium, decamethonium.

42

Side effects of depolarising blockers?

Bradycardia,
Prolonged paralysis.

43

Stuff that enhance cholinergic transmission.

Cholinesterase inhibitors or anticholinesterases.

44

Examples of irreversible antivholinesterase?

In insecticides. Ecothipate.

45

Reversible anticholinesterases.

Stigmines, edrophonium.

46

Use of anticholinesterase?

Treat myasthenia gravis.