Flashcards in Drugs affecting ANS Deck (51)
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1
length of symp fibers
short pre and long post
2
length of para fibers
long pre and short post
3
three major events at synapse
1. release NT
2. receptor binding and signal transduction
3. termination of NT
4
How can you terminate NT?
1. enzymatic degradation
2. reuptake via monoamine transporter
3. diffusion
5
where is ACh released?
1. para pre and post ganglionic neurons
2. symp preganglionic neurons
3. symp postganglionic neurons that innervate most sweat glands
6
where is N,m receptors found?
NMJ
7
binding of ACh N,m receptors
constriction
8
were is N,n receptors found?
autonomic ganglion, adrenal medulla, CNS
9
binding of ACh at N,n receptors at autonomic ganglionic
propagate AP
10
binding of ACh at N,n receptors at adrenal medulla
release EPI and NE
11
binding of ACh at N,n receptors in CNS
multiple effects
12
where is M1 receptors found?
salivary glands and stomach
13
where is M2 receptors found?
cardiac muscle
14
where are M3 receptors found?
GI, glands, pupil, bronchiole and bladder and smooth muscle
15
where are M4 and M5 receptors located?
CNS
16
binding of ACh at M1 receptors on salivary glands and stomach
increase salivary and gastric secretion
17
binding of ACh at M2 receptors on cardiac muscle
lower HR
18
binding of ACh at M3 receptors on GI
increase gastric emptying and increase gut motility
19
binding of ACh at M3 receptors on sweat glands
sweat gland secretion
20
binding of ACh at M3 receptors on pupil
miosis (constriction)
21
binding of ACh at M3 receptors on smooth muscle in bronchial and bladder
constriction
22
what releases EPI?
adrenal medulla
23
what releases NE?
adrenal medulla and symp postganglionic neurons
24
what releases DA?
symp postganglionic neurons that innervate renal vascular muscle
25
where does EPI preferentially binds?
alpha, beta 1-2 receptors
26
where does NE preferentially binds?
alpha and beta1,3 receptors
27
effect of binding alpha1 on vascular smooth muscle
contraction --> increase bp
28
effect of binding alpha2 on some vascular smooth muscle
contraction --> increase bp
29
effect of binding beta1 on heart
increase heart rate and force of contraction --> increase bp
30