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Flashcards in Drugs affecting ANS Deck (51):
1

length of symp fibers

short pre and long post

2

length of para fibers

long pre and short post

3

three major events at synapse

1. release NT
2. receptor binding and signal transduction
3. termination of NT

4

How can you terminate NT?

1. enzymatic degradation
2. reuptake via monoamine transporter
3. diffusion

5

where is ACh released?

1. para pre and post ganglionic neurons
2. symp preganglionic neurons
3. symp postganglionic neurons that innervate most sweat glands

6

where is N,m receptors found?

NMJ

7

binding of ACh N,m receptors

constriction

8

were is N,n receptors found?

autonomic ganglion, adrenal medulla, CNS

9

binding of ACh at N,n receptors at autonomic ganglionic

propagate AP

10

binding of ACh at N,n receptors at adrenal medulla

release EPI and NE

11

binding of ACh at N,n receptors in CNS

multiple effects

12

where is M1 receptors found?

salivary glands and stomach

13

where is M2 receptors found?

cardiac muscle

14

where are M3 receptors found?

GI, glands, pupil, bronchiole and bladder and smooth muscle

15

where are M4 and M5 receptors located?

CNS

16

binding of ACh at M1 receptors on salivary glands and stomach

increase salivary and gastric secretion

17

binding of ACh at M2 receptors on cardiac muscle

lower HR

18

binding of ACh at M3 receptors on GI

increase gastric emptying and increase gut motility

19

binding of ACh at M3 receptors on sweat glands

sweat gland secretion

20

binding of ACh at M3 receptors on pupil

miosis (constriction)

21

binding of ACh at M3 receptors on smooth muscle in bronchial and bladder

constriction

22

what releases EPI?

adrenal medulla

23

what releases NE?

adrenal medulla and symp postganglionic neurons

24

what releases DA?

symp postganglionic neurons that innervate renal vascular muscle

25

where does EPI preferentially binds?

alpha, beta 1-2 receptors

26

where does NE preferentially binds?

alpha and beta1,3 receptors

27

effect of binding alpha1 on vascular smooth muscle

contraction --> increase bp

28

effect of binding alpha2 on some vascular smooth muscle

contraction --> increase bp

29

effect of binding beta1 on heart

increase heart rate and force of contraction --> increase bp

30

effect of binding beta1 on juxtaglomerular cells

increase renin release --> increase bp

31

effect of binding beta2 on vascular smooth muscle

relaxation --> decrease bp

32

Lung: β2 →

bronchodilation

33

GI: α, β1/2 →

decrease motility

34

GI:α, β2 →

sphincter contraction

35

Salivary glands: α →

constriction

36

Ocular: α1 →

mydriasis (dilation)

37

Pancreas: α2 →

lower insulin release

38

Pancreas β2 →

increase insulin release

39

GU smooth muscle: α1 →

sphincter contraction

40

Adipose: α2 →

lower lipolysis

41

Adipose: β2,3 →

increase lipolysis

42

Hepatic: α1, β2 →

increase glycogenolysis/gluconeogenesis

43

what is the major mode of termination of catecholamines

reuptake via transporters

44

degrading enzyme found in mitochondrial membrane of most cell types

MAO

45

degrading enzyme found in liver, neurons and extracellularly

COMT

46

isoform of MAO that degrades serotonin (5HT), DA, NE, E

MAO-A

47

isoform of MAO that degrades DA more rapidly (found in blood platelets)

MAO-B

48

what does COMT degrade?

DA, NE, EPI

49

Where does sympathetic ganglionic fibers originate from?

thoracic-lumbar of spinal cord

50

Where does parasympathetic ganglionic fibers originate from?

cranio-sacral of spinal cord

51

why is ANS a good target for drugs?

ANS innervates almost every organ