Flashcards in Drugs affecting ANS Deck (51):
length of symp fibers
short pre and long post
length of para fibers
long pre and short post
three major events at synapse
1. release NT
2. receptor binding and signal transduction
3. termination of NT
How can you terminate NT?
1. enzymatic degradation
2. reuptake via monoamine transporter
where is ACh released?
1. para pre and post ganglionic neurons
2. symp preganglionic neurons
3. symp postganglionic neurons that innervate most sweat glands
where is N,m receptors found?
binding of ACh N,m receptors
were is N,n receptors found?
autonomic ganglion, adrenal medulla, CNS
binding of ACh at N,n receptors at autonomic ganglionic
binding of ACh at N,n receptors at adrenal medulla
release EPI and NE
binding of ACh at N,n receptors in CNS
where is M1 receptors found?
salivary glands and stomach
where is M2 receptors found?
where are M3 receptors found?
GI, glands, pupil, bronchiole and bladder and smooth muscle
where are M4 and M5 receptors located?
binding of ACh at M1 receptors on salivary glands and stomach
increase salivary and gastric secretion
binding of ACh at M2 receptors on cardiac muscle
binding of ACh at M3 receptors on GI
increase gastric emptying and increase gut motility
binding of ACh at M3 receptors on sweat glands
sweat gland secretion
binding of ACh at M3 receptors on pupil
binding of ACh at M3 receptors on smooth muscle in bronchial and bladder
what releases EPI?
what releases NE?
adrenal medulla and symp postganglionic neurons
what releases DA?
symp postganglionic neurons that innervate renal vascular muscle
where does EPI preferentially binds?
alpha, beta 1-2 receptors
where does NE preferentially binds?
alpha and beta1,3 receptors
effect of binding alpha1 on vascular smooth muscle
contraction --> increase bp
effect of binding alpha2 on some vascular smooth muscle
contraction --> increase bp
effect of binding beta1 on heart
increase heart rate and force of contraction --> increase bp
effect of binding beta1 on juxtaglomerular cells
increase renin release --> increase bp
effect of binding beta2 on vascular smooth muscle
relaxation --> decrease bp
Lung: β2 →
GI: α, β1/2 →
GI:α, β2 →
Salivary glands: α →
Ocular: α1 →
Pancreas: α2 →
lower insulin release
Pancreas β2 →
increase insulin release
GU smooth muscle: α1 →
Adipose: α2 →
Adipose: β2,3 →
Hepatic: α1, β2 →
what is the major mode of termination of catecholamines
reuptake via transporters
degrading enzyme found in mitochondrial membrane of most cell types
degrading enzyme found in liver, neurons and extracellularly
isoform of MAO that degrades serotonin (5HT), DA, NE, E
isoform of MAO that degrades DA more rapidly (found in blood platelets)
what does COMT degrade?
DA, NE, EPI
Where does sympathetic ganglionic fibers originate from?
thoracic-lumbar of spinal cord
Where does parasympathetic ganglionic fibers originate from?
cranio-sacral of spinal cord