Drugs - Antipsychotic Drugs Misc

Question 1

What is another name for antipsychotics?

Answer 1

Neuroleptic

Question 2

What do first generation antipsychotics block?

Answer 2

D2-like dopamine receptors

Question 3

What do second generation antipsychotics (atypical) block?

Answer 3

5HT-2A and D2 receptors

Question 4

Which was the first atypical agent approved in the US?

Answer 4

Clozapine (1990)

Question 5

In schizophrenia, there is too little D1 activity in the pre frontal cortex. What do we want to block in the pre-frontal cortex and what do we want to block in the nucleus accumbens, and what will each blockage control?

Answer 5

PFC: block 5HT-2A and D2 (controls negative symptoms)

N. Accumbens: block D2 (controls positive symptoms)

Question 6

Which agent causes more tardive dyskinesia than other typical antipsychotics?

Answer 6

Haloperidol

Question 7

Which agent causes less tardive dyskinesia than other typical antipsychotics?

Answer 7

Thioridazine

Question 8

Which combination drug is given to people to reduce their body temperature because it allows you to assume the temperature of the surroundings?

Answer 8

Droperidol + Fentanyl = INOVAR

Question 9

What makes atypical antipsychotics atypical?

Answer 9

They produce less EPS effects than conventional antisychotics

Question 10

Which agent has a dirty profile because it blocks many receptors, giving it an advantage?

Answer 10

Clozapine

Question 11

Which is the most effective antipsychotic and has no tardive dyskinesia?

Answer 11

Clozapine

Question 12

Which pure 5HT-2A antagonist, when used in combination with a typical antipsychotic, improved negative symptoms, however when used alone was not effective?

Answer 12

Ritanserin

Question 13

Why doesn’t Quetiapine fit the profile of a antipsychotic?

Answer 13

Because it has more D2 than 5HT-2A blocking activity