Drugs Employed in GI Disease 2 Flashcards Preview

MS2 Unit 6 Pharm > Drugs Employed in GI Disease 2 > Flashcards

Flashcards in Drugs Employed in GI Disease 2 Deck (28):
1

lifestyle measures to prevent GERD

elevation of the hrad of the bed, avoidance of food/drink 2-3 hours before bedtime. avoidance of fatty or spicy foods. avoidance of cigs/booze. weight loss. liquid antacid. pregnancy.

2

what do you give if there are persistent GERD symptoms?

alginic acid antacids, promotility drugs, H2 receptor blockers

3

what do you give if non-response or relapse or Barrett's esophagus?

H2 receptor blockers regular or double dose, or H2 blocker + promotility agent, or Proton pump inhibitors, or antireflux surgery

4

metochlopramide

promotility drug. peripheral dopamine antagonist. increases peristalsis. tightens lower esophogeal sphincter. can cause tremor

5

cisapride

cant be prescribed due to sudden cardiac death. increases peristalsis. tightens lower esophogeal sphincter.

6

treatment goals for vomiting

reverse underlying local problems causing gastric irritation, treat or eliminate the problems causing CNS stimulation, treat pain

7

prochlorperazine

phenothiazine antiemetic. CNS interaction with dopaminergic receptor. antagonist. can cause torticollis.

8

promethazine

phenothiazine antiemetic. antihistaminic, anticholinergic, causes somnolence in old people

9

trimethobenzamide

benzamide antiemetic. unknown effect on CRTZ. used in kids.

10

metochlopramide

benzamide antiemetic. used in cancer chemo patients. CNS and peripheral dopaminergic receptor antagonism.

11

THC

suppresses CRTZ by probable anticholinergic mechanism

12

ondansetron

serotonin receptor antagonist.

13

what 2 serotonin receptor antagonists are used in anesthesia related vomiting?

granesitron, dolasetron.

14

treatment of gastroparesis

promotility drugs. can also put a pacemaker in to stimulate paristalsis

15

treatment goals of diarrhea

prolong GI transit time. reduce cramps. try to minimize systemic side effects.

16

anticholinergics used to stop diarrhea

atropine sulfate. relaxes all bowel smooth muscle

17

opioid agonists to stop diarrhea

interact with mu or sigma receptors in GI tract. loperamide, diphenoxylate. dont give diphenox to kids. loperamide is super safe. these drugs contract the gut.

18

colloids and pectins for diarrhea

metamucil (colloid)
kaopectate (pectin)
absorb water.

19

irritants or stimulants for constipation

irritate colon and cause peristalsis
castor oil, cascara sagrada, senna extract, bisacodyl, phenolphthalein.

20

osmotic cathartics for constipation

magnesium citrate, magnesium sulfate, sodium sulfate, milk of magnesia, sodium phosphate, lactulose

21

bulk forming hydrophilic colloids for constipation

psyllium seed. methycellulose. sodium carboxymthyl cellulose

22

lubricant and fecal softeners for constipation

mineral oil. dioctyl sodium sulfo-succinate. poloxalkol.

23

amitizia

for constipation. chloride channel activator

24

linzess

for constipation. stimulates cGMP and results in chloride and bicarb secretion

25

naloxegol

for constipation. mu opioid receptor antagonist. used in opioid constipation

26

anti-inflammatories for IBD

mesalamine, sulfasalazine, olsalazine.

27

immunosuppressive agents for IBD

azathioprine. corticosteroids. methotrexate. biologics. cyclosporine

28

IBS-C vs IBS D treatments

bulk forming agents, opioids (IBS-D), cathartics (osmotic IBS-C), anticholinergics, antidepresents, serotonergic antagonists, serotonergic agonists.