Flashcards in Drugs Employed in GI Disease 2 Deck (28):
lifestyle measures to prevent GERD
elevation of the hrad of the bed, avoidance of food/drink 2-3 hours before bedtime. avoidance of fatty or spicy foods. avoidance of cigs/booze. weight loss. liquid antacid. pregnancy.
what do you give if there are persistent GERD symptoms?
alginic acid antacids, promotility drugs, H2 receptor blockers
what do you give if non-response or relapse or Barrett's esophagus?
H2 receptor blockers regular or double dose, or H2 blocker + promotility agent, or Proton pump inhibitors, or antireflux surgery
promotility drug. peripheral dopamine antagonist. increases peristalsis. tightens lower esophogeal sphincter. can cause tremor
cant be prescribed due to sudden cardiac death. increases peristalsis. tightens lower esophogeal sphincter.
treatment goals for vomiting
reverse underlying local problems causing gastric irritation, treat or eliminate the problems causing CNS stimulation, treat pain
phenothiazine antiemetic. CNS interaction with dopaminergic receptor. antagonist. can cause torticollis.
phenothiazine antiemetic. antihistaminic, anticholinergic, causes somnolence in old people
benzamide antiemetic. unknown effect on CRTZ. used in kids.
benzamide antiemetic. used in cancer chemo patients. CNS and peripheral dopaminergic receptor antagonism.
suppresses CRTZ by probable anticholinergic mechanism
serotonin receptor antagonist.
what 2 serotonin receptor antagonists are used in anesthesia related vomiting?
treatment of gastroparesis
promotility drugs. can also put a pacemaker in to stimulate paristalsis
treatment goals of diarrhea
prolong GI transit time. reduce cramps. try to minimize systemic side effects.
anticholinergics used to stop diarrhea
atropine sulfate. relaxes all bowel smooth muscle
opioid agonists to stop diarrhea
interact with mu or sigma receptors in GI tract. loperamide, diphenoxylate. dont give diphenox to kids. loperamide is super safe. these drugs contract the gut.
colloids and pectins for diarrhea
irritants or stimulants for constipation
irritate colon and cause peristalsis
castor oil, cascara sagrada, senna extract, bisacodyl, phenolphthalein.
osmotic cathartics for constipation
magnesium citrate, magnesium sulfate, sodium sulfate, milk of magnesia, sodium phosphate, lactulose
bulk forming hydrophilic colloids for constipation
psyllium seed. methycellulose. sodium carboxymthyl cellulose
lubricant and fecal softeners for constipation
mineral oil. dioctyl sodium sulfo-succinate. poloxalkol.
for constipation. chloride channel activator
for constipation. stimulates cGMP and results in chloride and bicarb secretion
for constipation. mu opioid receptor antagonist. used in opioid constipation
anti-inflammatories for IBD
mesalamine, sulfasalazine, olsalazine.
immunosuppressive agents for IBD
azathioprine. corticosteroids. methotrexate. biologics. cyclosporine