Drugs for dyslipidemia

Question 1

What drugs fall under the Statin class of dyslipidemia drugs?

Answer 1

Atorvastatin

Rosuvastatin

Simvastatin

Ptavastatin

Lovastatin

Pravastatin

Fluvastatin

Question 2

MOA of statins?

Answer 2

Inhibitors of HMG coA reductase, decreasing de novo sysnthesis of cholesterol.

First line therapy for reducing LDL

Question 3

How does Niacin treat dyslipidemia?

Answer 3

inhibits lipolysis of TG by reducing free fatty acid release.

The liver thus produces less VLDL which decreases circulating LDL levels

Question 4

What drugs fall under the fibrate class of drugs that treat dyslipidemias?

Answer 4

Gemfibrozil

Fenofibrate

Question 5

MOA of fibrate drug class

Answer 5

Active PPAR-α which leads to an increase in LPL expression

LPL increases fatty acid uptake and thus decreases levels of triglycerides (first line therapy for lowering TG)

Question 6

Drugs in the bile acid sequestrants (resins) class

Answer 6

Colestipol

Cholestyramine

Colesevelam

Question 7

MOA of bile acid resins

Answer 7

Bind to bile acids and increase their excretion, which enhances the conversion of cholesterol into bile acid.

The decline in cholesterol stimulates release of LDL receptors and thus increasing LDL clearance

Question 8

What drug is a cholesterol absorption inhibitor?

Answer 8

Ezetimibe

Question 9

What drugs are used to treat homozygous familial hypercholesterolemia?

Answer 9

Lomitapide

Mipomersen

PCSK9 inhibitors