Drugs used in IHD

Question 1

What is the MOA of Nitrates?

Answer 1

Organic nitrates are reduced by thiols to release NO

NO induces venous dilation which decreases preload and in turn decreases myocardial O2 demand

NO less often leads for coronary A. dilation and relief of coronary vasospasms (useful in Prinzmetal angina)

Question 2

What drugs are in the nitrate class

Answer 2

Nitroglycerin

Isosorbide dinitrate

Isosorbide mononitrate

Question 3

What drugs are in the dihydropyridine (non-cardioactive) class of calcium channel blockers?

Answer 3

Amlodipine

Nifedipine

Nicardipine

Question 4

What drugs are in the non-dihydropyridine (cardioactive) class of calcium channel blockers?

Answer 4

Verapamil

Diltiazem

Question 5

What non-selective beta blockers are used to treat IHD?

Answer 5

Propranolol

Nadolol

Question 6

What β1 selective beta blockers are used in treating IHD?

Answer 6

Metoprolol

Atenolol

Question 7

How do CCB treat angina?

Answer 7

Decrease O2 demand through dilation of peripheral arterioles, decreasing PVR and afterload thus decreasing BP

Increase blood supply by dilating coronary aa to relieve vasospasms in Prinzmetal angina

Question 8

What is the MOA of beta-blockers in angina?

Answer 8

Decrease myocardial O2 demand

Question 9

What type of angina are beta-blockers typically used for?

Answer 9

Stable angina

Question 10

What drug class is the first line therapy for prinzmetal angina?

Answer 10

CCB